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Last Updated: March 29, 2024

Claims for Patent: 5,886,148


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Summary for Patent: 5,886,148
Title: Parathyroid hormone receptor
Abstract:DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed.
Inventor(s): Segre; Gino V. (Wayland, MA), Kronenberg; Henry M. (Belmont, MA), Abou-Samra; Abdul-Badi (Plainville, MA), Juppner; Harald (Boston, MA), Potts, Jr.; John T. (West Newton, MA), Schipani; Ernestina (Boston, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Application Number:08/468,249
Patent Claims:1. An essentially purified preparation of a polypeptide comprising the amino acid sequence of a naturally-occurring mammalian parathyroid hormone receptor, said receptor having an amino acid sequence with at least 75% identity to the amino acid sequence of SEQ ID NO: 20.

2. A polypeptide consisting of at least six amino acids, and less than the complete amino acid sequence, of the human parathyroid hormone receptor represented by SEQ ID NO: 21, wherein said polypeptide binds parathyroid hormone or parathyroid hormone-related protein and comprises an amino acid sequence selected from the group consisting of:

(a) (SEQ ID NO:5),

(b) (SEQ ID NO:6),

(c) (SEQ ID NO:7),

(d) (SEQ ID NO:8),

(e) (SEQ ID NO:9),

(f) (SEQ ID NO:10),

(g) (SEQ ID NO:11),

(h) (SEQ ID NO:12),

(i) (SEQ ID NO:13), and

(j) a fragment of any one of (a)-(i).

3. The polypeptide of claim 2, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of:

(a) (SEQ ID NO:5),

(b) (SEQ ID NO:6),

(c) (SEQ ID NO:7),

(d) (SEQ ID NO:8),

(e) (SEQ ID NO:9),

(f) (SEQ ID NO:10),

(g) (SEQ ID NO:11),

(h) (SEQ ID NO:12), and

(i) (SEQ ID NO:13).

4. The preparation of claim 1, wherein the receptor is a human parathyroid hormone receptor encoded by SEQ ID NO:21.

5. The preparation of claim 1, wherein the receptor is an opossum or rat parathyroid hormone receptor encoded by SEQ ID NO:18, SEQ ID NO:19, or SEQ ID NO:20.

6. A composition comprising (a) a polypeptide having the amino acid sequence of a naturally-occurring mammalian parathyroid hormone receptor, and (b) a pharmaceutically-acceptable carrier, wherein said composition is substantially free from proteins and lipids with which said receptor is naturally associated.

7. The composition of claim 6, wherein the receptor is a human parathyroid hormone receptor.

8. A composition comprising (a) the polypeptide of claim 1, and (b) a pharmaceutically-acceptable carrier.

9. A composition comprising (a) the polypeptide of claim 3, and (b) a pharmaceutically-acceptable carrier.

10. The preparation of claim 1, wherein the polypeptide was produced upon expression of a recombinant DNA molecule encoding the receptor.

11. The preparation of claim 10, wherein the antisense strand of the recombinant DNA molecule hybridizes under under conditions of high stringency to a hybridization probe consisting of an 18-nucleotide portion of a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, and SEQ ID NO:4.

12. The preparation of claim 10, wherein the antisense strand of the recombinant DNA molecule hybridizes under conditions of high stringency to a hybridization probe consisting of a 30-nucleotide portion of a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, and SEQ ID NO:4.

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