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Last Updated: April 25, 2024

Claims for Patent: 5,880,255

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Summary for Patent: 5,880,255

Title:	Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct of PEG and granulocyte-macrophage colony stimulating factor
Abstract:	The invention relates to fractionating a mixture of polyethylene glycol (PEG)-protein adducts having different degrees of PEG substitution by partitioning the PEG-protein adducts in a PEG-containing aqueous biphasic system according to the degree of PEG substitution. A new PEG-gm-CSF obtained by the process is useful in pharmaceutical compositions for use in therapeutic or diagnostic methods.
Inventor(s):	Delgado; Cristina (London, GB), Francis; Gillian Elizabeth (London, GB), Fisher; Derek (London, GB)
Assignee:	PolyMASC Pharmaceuticals plc (London, GB2)
Application Number:	08/422,992
Patent Claims:	1. A process for producing a biologically-active PEG-protein adduct comprising reacting a 2,2,2-trifluoreothane sulphonyl derivative of a PEG having a single derivatizable hydroxyl group with a recombinantly produced protein selected from the group consisting of an antibody, asparaginase, glutaminase-asparaginase, uricase, arginase superoxide dismutase, lactoferrin, streptokinase, plasma-streptokinase complex, adenosine deaminase, a peptide hormone, a mast cell gowth factor, G-CSF and GM-CSF. 2. A process for producing a biologically-active PEG-protein adduct comprising reacting a 2,2,2-tdfluoroethane sulphonyl monomethoxy-PEG with a recombinantly produced protein selected from the group consisting of an antibody, asparaginase, glutaminiase-asparaginase, uricase, arginase, superoxide dismutase, lactoferrin, streptokinase, plasma-streptokinase complex, adenosine deaminase, a peptide hormone, a mast cell growth factor, G-CSF and GM-CSF. 3. A process according to claim 1 wherein the peptide hormone is insulin. 4. A process according to claim 2 wherein the peptide hormone is insulin. 5. A PEG-protein adduct obtainable by the process of claims 1. 6. A PEG-protein adduct obtainable by the process of claim 2. 7. A PEG-protein adduct obtainable by the process of claim 3. 8. A PEG-protein adduct obtainable by the process of claim 4.

Details for Patent 5,880,255

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978	⤷ Try a Trial	2016-03-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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