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Last Updated: April 19, 2024

Claims for Patent: 5,872,221

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Summary for Patent: 5,872,221

Title:	Antibody having binding specificity to parathyroid hormone related protein (PTHrP) and kit comprising the same
Abstract:	Antibody reagents capable of binding epitopes of PTHrP and a kit for the detection of PTHrP or fragments thereof comprising one or more antibody reagents capable of binding to epitopes of PTHrP.
Inventor(s):	Martin; Thomas J. (Kew, AU), Moseley; Jane M. (North Balwyn, AU), Kemp; Bruce E. (Kew, AU), Wettenhall; Richard E. H. (Camberwell, AU)
Assignee:	The University of Melbourne (Victoria, AU)
Application Number:	08/008,696
Patent Claims:	1. An antibody having binding specificity to a N-terminal fragment of parathyroid hormone-related protein (PTHrP), wherein said PTHrP has a molecular weight of between 15 to 25 kilodaltons, as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis, and wherein said N-terminal fragment is PTHrP(1-34) peptide having the following amino acid sequence: ##STR2## 2. An antibody having binding specificity to a substituted fragment of PTHrP(1-34) peptide selected from the group consisting of: ##STR3## 3. The antibody of claim 1 or 2, wherein said antibody is labelled with a detectable marker. 4. A kit comprising an antibody having binding specificity to an N-terminal fragment of parathyroid hormone-related protein (PTHrP), wherein said PTHrP has a molecular weight of between 15 to 25 kilodaltons, as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis, and wherein said N-terminal fragment is PTHrP(1-34) having the following amino acid sequence: ##STR4## 5. A kit comprising an antibody having binding specificity to a substituted fragment of PTHrP(1-34) selected from the group consisting of: ##STR5## 6. The kit of claim 4 or 5, wherein said antibody is labelled with a detectable marker. 7. The kit of claim 4 or 5, wherein said kit additionally comprises a reagent for detecting said antibody. 8. The kit of claim 4 or 5, wherein said kit additionally comprises: (i) a support matrix upon which an assay to detect binding of said antibody to said PTHrP may be performed; and (ii) a diluent for said antibody.

Details for Patent 5,872,221

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2016-02-16
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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