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Last Updated: March 29, 2024

Claims for Patent: 5,855,987


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Summary for Patent: 5,855,987
Title: Bioactive conjugates of cellulose with amino compounds
Abstract:Polymers containing a plurality of free hydroxy groups, such as cellulose, agarose or polyvinyl alcohol, are contacted in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound, e.g. pyridine, pyrrole, pyridazine, their partially or fully hydrogenated analogs and any of these which may be substituted, in a pre-activation step prior to reaction with reactant for free hydroxy groups in the polymer, the polymer-bound residue of which reactant may be thereafter reacted in turn with amino compounds containing at least one unsubstituted N-attached hydrogen atom, e.g. proteins, thereby to form amine-polymer conjugates. The invention further relates to a powder, bandage, patch or like cover for application to wounds which has been manufactured from polymer containing a plurality of hydroxy groups by a process which includes the step of providing an amine conjugated to the polymer; the amine may be, e.g., trypsin, chymotrypsin, lysozyme, collagenase, albumin and hyaluronidase.
Inventor(s): Margel; Shlomo (Rehovot, IL), Sturchak; Sophia (Tel Aviv, IL)
Assignee: Bar Ilan University (Ramat Gan, IL)
Application Number:08/416,351
Patent Claims:1. A textile web bandage, patch or like bandage, patch or like wound cover derived from a polymer composition comprising at least one member selected from the group consisting of cellulose, polysaccharides other than cellulose and polyvinyl alcohol and its copolymers which contain a plurality of free hydroxy groups, which said at least one member has been subjected to preactivation by treatment with at least one N-heterocyclic compound for a period of time sufficient to increase the capacity of said at least one member for reaction with a reactant;

said reactant being selected from the group consisting of cyanogen halides, carbonate esters, halogenated s-triazines, haloformates, sulfonyl halides and N-heterocyclic compounds containing active halogen atoms on the heterocyclic nucleus; and

wherein the preactivation heterocyclic compound is selected from the group consisting of pyridine, pyrrole and pyridazine, partially hydrogenated analogs thereof, fully hydrogenated analogs thereof, and any of the foregoing which contain at least one substituent selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, non-active fluorine, chlorine, bromine and trifluoromethyl.

2. The preactivated polymer of claim 1, which has been conjugated with at least one amino compound, the amino compound containing prior to conjugation at least one primary or secondary amine group.

3. The preactivated and conjugated polymer of claim 2, wherein said at least one amino compound is at least one protein.

4. The preactivated and conjugated polymer of claim 3, wherein said at least one protein is selected from trypsin, chymotrypsin, lysozyme, collagenase, albumin and hyaluronidase.

Details for Patent 5,855,987

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 05/05/2004 ⤷  Try a Trial 2016-01-05
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 12/02/2004 ⤷  Try a Trial 2016-01-05
Amphastar Pharmaceuticals, Inc. AMPHADASE hyaluronidase Injection 021665 10/26/2004 ⤷  Try a Trial 2016-01-05
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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