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Last Updated: March 28, 2024

Claims for Patent: 5,837,260


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Summary for Patent: 5,837,260
Title: Chimeric hepatitis A vaccine
Abstract:A full-length cDNA copy of an attenuated, cell culture-adapted hepatitis-A virus genome has been constructed. The HAV cDNA when inserted, without the oligo (dG) oligo (dC) tails, into an RNA transcription vector yielded a plasmid designated pHAV/7. Transfection of monkey kidney cells with pHAV/7 DNA yielded HAV. Transfection with RNA transcripts produced in vitro from pHAV/7 yielded about 10-fold more HAV than transfection with pHAV/7 DNA. HAV thus produced are useful as a vaccine.
Inventor(s): Cohen; Jeffrey I. (Brighton, MA), Purcell; Robert H. (Boyds, MD), Feinstone; Stephen M. (Washington, DC), Ticehurst; John R. (Bethesda, MD)
Assignee: The United of America as represented by the Department of Health and Human Services (Washington, DC)
Application Number:08/473,304
Patent Claims:1. An attenuated, cell-culture adapted, infectious hepatitis A virus of the HM-175 strain produced by cells containing a nucleic acid molecule which has a nucleic acid sequence corresponding to the sequence of HAV HM-175/7 MK-5 except for the nucleotides at positions 7027 and 7425 which are those of wild-type hepatitis A virus HM-175.

2. An attenuated, cell-culture adapted, infectious hepatitis A virus produced by cells containing a nucleic acid molecule contained in an expression vector having ATCC deposit number 67495.

3. A killed hepatitis A vaccine comprising the hepatitis A virus of claim 1.

4. A killed hepatitis A vaccine comprising the hepatitis A virus of claim 2.

5. A live hepatitis A vaccine comprising the hepatitis A virus of claim 1.

6. A live hepatitis A vaccine comprising the hepatitis A virus of claim 2.

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