Claims for Patent: 5,817,055

Summary for Patent: 5,817,055

Title:	Dual-chamber injection cartridge
Abstract:	An injection cartridge of the dual-chamber type, which comprises a cylindrical cartridge barrel having a front chamber for a solid product and a rear chamber for a liquid product. The chambers are sealingly separated by a displaceable piston of a resilient material, and have an openable bypass connection for liquid from the rear chamber to the front chamber and a resilient sealing closure of the front end of the front chamber.
Inventor(s):	Ljungquist; Olle (Taby, SE)
Assignee:	Pharmacia & Upjohn Aktiebolag (Stockholm, SE)
Application Number:	08/477,607
Patent Claims:	1. An injection cartridge of the dual-chamber type, comprising a cylindrical cartridge barrel having a front chamber for a solid component and a rear chamber for a liquid component of an injectable preparation, said chambers being sealingly separated from each other by a displaceable front piston of a resilient material, an openable bypass connection for liquid from the rear chamber to the front chamber, and a pierceable closure sealing the front end of the front chamber, characterized in that in the barrel of the cartridge is arranged a constriction such that said cartridge barrel has a non-circular cross-section at said constriction, that before said liquid bypass connection has been opened, said separating front piston is positioned close to the rear of said constriction, such that said constriction exerts a resistance against any forward displacement of said front piston, such that said front piston is prevented from moving forward when there is a vacuum in front of it and essentially atmospheric pressure behind it, and that said front piston during a forward displacement through said constriction while overcoming said resistance is deformed such that said liquid bypass connection is established. 2. An injection cartridge according to claim 1, characterized in that the barrel of the cartridge has an oval cross-section at said constriction. 3. An injection cartridge according to claim 2, characterized in that the rear chamber, containing the liquid component, is closed at its rear end by a displaceable rear piston which on being urged toward exerts a pressure on the front piston to urge it into and through said constriction while overcoming said resistance. 4. An injection cartridge according to claim 2, characterized in that the liquid component in the rear chamber is sterile water or a sterile aqueous solution. 5. An injection cartridge according to claim 1, characterized in that the barrel of the cartridge has a dumbbell-shaped cross-section at said constriction. 6. An injection cartridge according to claim 5, characterized in that the rear chamber, containing the liquid component, is closed at its rear end by a displaceable rear piston which on being urged forward exerts a pressure on the front piston to urge it into and through said constriction while overcoming said resistance. 7. An injection cartridge according to claim 5, characterized in that the liquid component in the rear chamber is sterile water or a sterile aqueous solution. 8. An injection cartridge according to claim 1, characterized in that the rear chamber, containing the liquid component, is closed at its rear end by a displaceable rear piston which on being urged forward exerts a pressure on the front piston to urge it into and through said constriction while overcoming said resistance. 9. An injection cartridge according to claim 8, characterized in that the liquid component in the rear chamber is sterile water or a sterile aqueous solution. 10. An injection cartridge according to claim 1, characterized in that the liquid component in the rear chamber is sterile water or a sterile aqueous solution.

Details for Patent 5,817,055

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2015-10-06