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Last Updated: April 24, 2024

Claims for Patent: 5,795,975

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Summary for Patent: 5,795,975

Title:	TNF receptor promoter
Abstract:	A DNA molecule containing the endogenous first intron-located p55 TNF-R gene promoter/enhancer sequence is provided. Also provided is a DNA molecule which contains a gene in operative association with a promoter sequence that includes the endogenous first intron-located p55 TNF-R gene promoter/enhancer sequence.
Inventor(s):	Wallach; David (Rehovot, IL), Kemper; Oliver (Bockenheim, DE), Kuhnert; Peter (Berne, CH)
Assignee:	Yeda Research and Development Co. Ltd. (Rehovot, IL)
Application Number:	08/532,309
Patent Claims:	1. A DNA molecule comprising the endogenous first intron-located p55 TNF-R gene promoter/enhancer sequence, provided that said molecule contains no more of the p55 TNF-R gene than the first intron thereof. 2. A DNA molecule in accordance with claim 1, wherein said molecule contains no more of the p55 TNF-R gene than the 1.7 kb PstI fragment of the 3' region of the first intron of the human p55 TNF-R gene. 3. A DNA molecule in accordance with claim 2, wherein said molecule contains no more of the p55 TNF-R gene than the 973 bp SacI-PstI fragment contained in said 1.7 kb PstI fragment, said SacI-PstI fragment having the sequence of SEQ ID NO:1. 4. A DNA molecule in accordance with claim 2, wherein said molecule contains no more of the p55 TNF-R gene than the 556 bp AurII-PstI fragment contained in said SacI-PstI fragment. 5. A DNA molecule consisting of the endogenous first intron-located p55 TNF-R gene promoter/enhancer sequence. 6. In a recombinant DNA molecule comprising a gene to be expressed, other than the p55 TNF-R gene, and a promoter sequence operatively associated therewith, which promoter sequence functions to promote the expression of said gene, the improvement wherein said promoter sequence comprises the endogenous first intron-located p55 TNF-R gene promoter/enhancer sequence. 7. A DNA molecule in accordance with claim 6, wherein said promoter sequence comprises the 556 bp AurII-PstI fragment contained in the SacI-PstI fragment of SEQ ID NO:1. 8. A DNA molecule in accordance with claim 6, wherein said promoter sequence comprises the 973 bp SacI-PstI fragment having the the sequence of SEQ ID NO:1. 9. A DNA molecule in accordance with claim 8, wherein said promoter sequence comprises the 1.7 kb PstI fragment of the 3' region of the first intron of the human p55 TNF-R gene.

Details for Patent 5,795,975

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2013-01-10
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2013-01-10
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2013-01-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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