Claims for Patent: 5,762,502

Summary for Patent: 5,762,502

Title:	Process for adhering composites to human teeth
Abstract:	A process for conditioning dentin surfaces in teeth to provide improved bonding strength between restorative materials and a tooth to be restored is disclosed. The process includes exposing a cut tooth surface to at least one enzyme, and then rinsing the tooth surface with water to remove any residual enzyme, prior to applying the restorative material.
Inventor(s):	Bahn; Arthur N. (St. Louis, MO), Stewart; Gregory P. (Godfrey, IL)
Assignee:
Application Number:	08/676,644
Patent Claims:	1. A process for conditioning dentin surfaces in teeth to provide improved bonding strength between restorative materials and a tooth to be restored comprises: exposing a cut tooth surface to at least one enzyme, and then rinsing the tooth surface to remove any residual enzyme, prior to applying the restorative material, to thereby etch the smear layer created during cutting of the tooth and thus provide a cut tooth surface having improved bonding strength when bonded to restorative materials. 2. The process of claim 1, wherein the step of exposing the tooth surface to at least one enzyme is performed using at lease one metalloproteinase. 3. The process of claim 2, wherein the step of exposing the tooth surface to at least one metalloproteinase is performed using at least one collagenase. 4. The process of claim 3, wherein the step of exposing the tooth surface to at least one collagenase is performed using a collagenase from Achromobacter iophasus. 5. The process of claim 3, wherein the step of exposing the tooth surface to at least one collagenase is performed using a mixture of collagenases from Clostridium histolyticum. 6. The process of claim 1, wherein the step of exposing the cut tooth surface to at least one enzyme is performed using a mixture of collagenase/dispase enzymes. 7. The process of claim 6, wherein the step of exposing the cut tooth surface to a mixture of collagenase/dispase enzymes is performed using a mixture of collagenase/dispase from Achromobacter iophasus/Bacillus polymyxa. 8. The process of claim 6, wherein the step of exposing the tooth surface to a mixture of collagenase/dispase is performed using a collagenase/dispase concentration of from about 0.625 mg/ml to about 1 mg/ml. 9. The process of claim 6, wherein the step of exposing the cut tooth surface to a mixture of collagenase/dispase is performed using a concentration of 1/16th of 1 mg/ml. 10. The process of claim 1, wherein the step of exposing the tooth surface to at least one enzyme is performed using a collagenolytic proteinase. 11. The process of claim 10, wherein the step of exposing the cut tooth surface to a collagenolytic proteinase is performed using a collagenolytic proteinase Paralithodes camtshatica hepatopancreas. 12. The process of claim 1, wherein the step of exposing the cut tooth surface to at least one enzyme is performed using a neutral protease. 13. The process of claim 1, wherein the step of exposing the cut tooth surface to at least one enzyme is performed for a period of time in the range of approximately one minute to approximately 20 minutes. 14. The process of claim 1, wherein the step of exposing the cut tooth surface to at least one enzyme is preceded by exposing the cut tooth surface to an acid. 15. The process of claim 14, wherein the step of exposing the cut tooth surface to an acid is performed for approximately one minute. 16. The process of claim 14, wherein the step of exposing the cut tooth surface to an acid is performed using phosphoric acid. 17. The process of claim 16, wherein the phosphoric acid is used at a concentration of approximately 37%, aqueous. 18. The process of claim 14, wherein the step of exposing the cut tooth surface to an acid is performed using polyacrylic acid. 19. The process of claim 1, wherein the step of rinsing is performed with water. 20. The process of claim 19, wherein the step of rinsing is performed for approximately twenty seconds.

Details for Patent 5,762,502

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2039-02-26