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Last Updated: April 19, 2024

Claims for Patent: 5,723,487


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Summary for Patent: 5,723,487
Title: Preparation of a product for treatment of colagen-related disorders
Abstract:This invention refers to a process for creating a product useful in the treatment of disorders related to collagen production and function.
Inventor(s): Sumi Horvath, deceased; Antonio (late of Santiago, CL), Tobar Goycolea, legal representative; by Judith (Santiago, CL), Sumi Horvath, legal representative; by Antonio (Vina del Mar, CL), Kiss Horvath, legal representative; by Dora (Santiago, CL)
Assignee:
Application Number:08/387,068
Patent Claims:1. A method of treating collagen related disorders comprising the following steps:

a) providing a solution of an ascorbate in ethanol;

b) providing a solution of sodium hydroxide dissolved in water;

c) mixing the ascorbate solution with the sodium hydroxide solution so that the molar ratio of sodium hydroxide to ascorbate is 0.7:1 and an alkaline pH is maintained;

d) mixing chloroform with the solution of step c in quantity sufficient to produce a crystalline substance;

e) collecting the crystalline substance;

f) determining a melting temperature of the crystalline substance;

g) maintaining the temperature of all steps below approximately 35.degree. C.;

h) administering to a mammal in need thereof a therapeutically effective amount of the crystalline substance, if the melting temperature observed in step f is approximately 170.degree. C.

2. The method of claim 1 wherein a therapeutically effective amount of the crystalline substance is approximately 100 mg.

3. The method of claim 1 wherein the mammal is chosen from the group consisting of feline animals and humans.

4. The method of claim 1 wherein the collagen related disorder is chosen from the group consisting of osteogenesis imperfecta and tumours that invade adjacent tissues by their collagenase activity.

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