Claims for Patent: 5,714,667
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Summary for Patent: 5,714,667
Title: | Mice lacking expression of CTLA-4 receptor |
Abstract: | Disclosed is a mouse in which expression of the gene encoding the CTLA-4 receptor is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line containing such construct. |
Inventor(s): | Waterhouse; Paul David (London, CA), Mak; Tak Wah (Toronto, CA) |
Assignee: | Amgen Canada Inc. (Mississauga, CA) |
Application Number: | 08/554,133 |
Patent Claims: | 1. A transgenic mouse homozygous for a disrupted CTLA-4 receptor gene, wherein said CTLA-4 receptor gene is disrupted by a selectable marker sequence introduced into said mouse or an
ancestor of said mouse at an embryonic stage, and wherein said disrupted CTLA-4 receptor gene results in said mouse exhibiting enlarged lymph nodes as compared to a wild type mouse.
2. A mouse of claim 1, wherein the disruption results in a null mutation of the gene encoding a CTLA-4 receptor. 3. A CTLA-4 receptor DNA knockout construct comprising a selectable marker sequence flanked by DNA sequences homologous to the CTLA-4 receptor gene, wherein when said construct is introduced into a mouse or an ancestor of a mouse at an embryonic stage, said selectable marker sequence disrupts the CTLA-4 receptor gene in said mouse and results in said mouse exhibiting enlarged lymph nodes as compared to a wild type mouse. 4. A vector comprising the CTLA-4 receptor DNA knockout construct of claim 3. 5. A CTLA-4 receptor DNA knockout construct according to claim 3, wherein said construct consists of, 5' to 3', a thymidine kinase cassette; the CTLA-4 receptor fragment 1 containing exon 1 and most of intron 1 as depicted in FIG. 1; a neo cassette; and the CTLA-4 receptor fragment 2 containing the 3' half of exon 3, all of intron 3, and most of exon 4 as depicted in FIG. 1. 6. A mouse E14 embryonic stem cell line comprising the CTLA-4 DNA receptor knockout construct of claim 3. |
Details for Patent 5,714,667
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2039-02-26 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2039-02-26 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2039-02-26 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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