Claims for Patent: 5,714,370
✉ Email this page to a colleague
Summary for Patent: 5,714,370
Title: | Thrombin and method of producing the same |
Abstract: | A thrombin of human or animal origin is free of infectious agents and is produced by activation of prothrombin subjected to a heat treatment for the inactivation of infectious agents. |
Inventor(s): | Eibl; Johann (Vienna, AT), Linnau; Yendra (Vienna, AT) |
Assignee: | Immuno Aktiengesellschaft (Vienna, AT) |
Application Number: | 08/458,082 |
Patent Claims: | 1. A pharmaceutical preparation comprising (i) a virus-safe human or animal thrombin and (ii) a coagulatively active salt, wherein the thrombin is obtained from a
virus-inactivated prothrombin-containing plasma fraction by exclusive activation with the coagulatively active salt.
2. The preparation according to claim 1, wherein the fraction comprises a prothrombin complex. 3. The preparation according to claim 2, wherein the prothrombin complex is activated. 4. The preparation according to claim 1, wherein the fraction comprises Factor VIII Inhibitor Bypassing Activity (FEIBA). 5. A pharmaceutical preparation comprising a virus-safe human or animal thrombin, wherein the thrombin is obtained from a virus-inactivated prothrombin-containing fraction by exclusive activation with a coagulatively active salt. 6. The preparation according to claim 5, wherein the fraction comprises a prothrombin complex. 7. The preparation according to claim 6, wherein the prothrombin complex is activated. 8. The preparation according to claim 5, wherein the fraction comprises FEIBA. 9. A method for producing a pharmaceutical preparation comprising (i) virus-safe thrombin of human or animal origin and (ii) a coagulatively active salt, comprising (a) preparing an activated prothrombin complex from a prothrombin-containing plasma fraction; (b) treating the activated prothrombin complex to inactivate contaminating viruses; (c) contacting the treated activated prothrombin complex with a coagulatively active salt to generate thrombin; and (d) preparing the pharmaceutical preparation with the generated thrombin. 10. The method according to claim 9, wherein the preparing comprises purifying thrombin by at least one method selected from the group consisting of ion exchange chromatography and affinity chromatography. 11. A method for producing a preparation comprising (i) virus-safe human or animal thrombin and (ii) a coagulatively active salt, comprising (a) treating an activated human or animal prothrombin complex to inactivate contaminating viruses; (b) contacting the treated activated prothrombin complex with a coagulatively active salt to generate virus-safe thrombin; and (c) formulating the preparation with the virus-safe thrombin from (b). 12. The method according to claim 11, further comprising purifying the generated virus-safe thrombin prior to (c) by at least one method selected from the group consisting of ion exchange chromatography and affinity chromatography to yield purified virus-safe thrombin. 13. A pharmaceutical preparation comprising a virus-safe human or animal thrombin, wherein the thrombin is obtained from a virus-inactivated prothrombin-containing fraction by the sole addition of a coagulatively active salt for activation. 14. The preparation according to claim 13, further comprising the coagulatively active salt. |
Details for Patent 5,714,370
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Baxalta Us Inc. | AUTOPLEX, FEIBA NF, FEIBA VH | anti-inhibitor coagulant complex | For Injection | 101447 | 12/21/1979 | ⤷ Try a Trial | 2015-02-03 |
Baxalta Us Inc. | AUTOPLEX, FEIBA NF, FEIBA VH | anti-inhibitor coagulant complex | For Injection | 101447 | 07/31/2000 | ⤷ Try a Trial | 2015-02-03 |
Baxalta Us Inc. | AUTOPLEX, FEIBA NF, FEIBA VH | anti-inhibitor coagulant complex | For Injection | 101447 | 08/11/2005 | ⤷ Try a Trial | 2015-02-03 |
Omrix Biopharmaceuticals Ltd | EVITHROM | thrombin, topical (human) | Solution | 125247 | 08/27/2007 | ⤷ Try a Trial | 2015-02-03 |
Omrix Biopharmaceuticals Ltd | EVITHROM | thrombin, topical (human) | For Injection | 125247 | 09/17/2009 | ⤷ Try a Trial | 2015-02-03 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.