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Last Updated: September 22, 2021

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Claims for Patent: 5,714,349

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Summary for Patent: 5,714,349
Title: Synthetic gene coding for human parathyroid hormone
Abstract:Disclosed are (1) a DNA containing a synthetic gene for expression of human parathyroid hormone represented by the following DNA sequence: TCTGTG TCCGAGATTC AGTTAATGCA TAACCTTGGC AAACATTTGA ACTCCATGGA GCGTGTAGAA TGGCTGCGTA AGAAGTTGCA GGATGTGCAC AATTTTGTTG CCTTAGGTGC CCCATTGGCT CCTCGTGATG CTGGTTCCCA AAGACCACGT AAAAAGGAAG ACAATGTCTT AGTTGAGAGC CATGAAAAAT CCCTAGGCGA GGCAGACAAG GCCGATGTGA ATGTATTAAC TAAAGCTAAA TCCCAG (2) a method for producing the DNA described in (1), which comprises enzymatically ligating a plurality of oligodeoxynucleotides to one another to form the DNA and inserting the DNA into a vector if necessary, (3) a transformant transformed by the DNA described in (1), and (4) a method for producing human parathyroid hormone which comprises cultivating the transformant described in (3), accumulating human parathyroid hormone in a culture medium, and collecting the same, whereby hPTH can be allowed to express in large amounts in a system using E. coli as a host.
Inventor(s): Fukuda; Tsunehiko (Kyoto, JP), Oshika; Yuri (Osaka, JP), Yamada; Takao (Osaka, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/689,190
Patent Claims:1. Plasmid pE-PTH.

2. An Escherichia coil transformed with plasmid pE-PTH.

3. A method for producing human parathyroid hormone which comprises cultivating an Escherichia coli transformed with plasmid pE-PTH under conditions suitable for expression of said human parathyroid hormone and recovering the same.

Summary for Patent: ⤷  Free Forever Trial

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan2-257491Sep 28, 1990
Japan3-056434Mar 20, 1991

Details for Patent 5,714,349

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ⤷  Free Forever Trial Takeda Chemical Industries, Ltd. (Osaka, JP) 2010-09-28 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ⤷  Free Forever Trial Takeda Chemical Industries, Ltd. (Osaka, JP) 2010-09-28 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ⤷  Free Forever Trial Takeda Chemical Industries, Ltd. (Osaka, JP) 2010-09-28 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ⤷  Free Forever Trial Takeda Chemical Industries, Ltd. (Osaka, JP) 2010-09-28 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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