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Last Updated: March 28, 2024

Claims for Patent: 5,703,207


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Summary for Patent: 5,703,207
Title: Protein active in humoral hypercalcemia of malignancy-PTHrP
Abstract:A sub-unit or fragment of parathyroid hormone related protein having the following characteristics: (a) an N-terminal amino acid sequence A V S E H Q L L H D K G K S I Q D L R R R F F L H H L I A E I H T A E I R A T S E V S P N; (b) a molecular weight between 15 to 25 kilodaltons, as determined by sodium dodecyl polyacrylamide gel electrophoresis under reducing and non-reducing conditions; and (c) a specific biological activity of at least about 6 mg equivalents of a peptide composed of amino acids 1-34 a parathyroid hormone related protein per mg protein as measured in an adenylate cyclase response assay.
Inventor(s): Martin; Thomas J. (Kew, AU), Moseley; Jane M. (North Balwyn, AU), Kemp; Bruce E. (Kew, AU), Wettenhall; Richard E. H. (Camberwell, AU)
Assignee: The University of Melbourne (Victoria, AU)
Application Number:08/352,622
Patent Claims:1. A substantially pure fragment of parathyroid hormone related protein (PTHrP) which comprises at least amino acids 1-16 of PTHrP, wherein PTHrP amino acids 1-34 comprise the sequence:

A V S E H Q L L H D K G K S I Q D L R R R F F L H H L I A E I H T A.

2. A substantially pure fragment of parathyroid hormone related protein according to claim 1 which comprises amino acids 1-34 of PTHrP.

3. A modified fragment of parathyroid hormone related protein (PTHrP) selected from the group consisting of:

[Glu.sup.8, Asn.sup.10, Cys.sup.11 ] parathyroid hormone related protein (1-11),

[Asn.sup.10 ] parathyroid hormone related protein (1-16), and

[Asn.sup.10, Tyr.sup.17 ] parathyroid hormone related protein (1-17),

wherein PTHrP amino acids 1-34 comprise the sequence:

A V S E H Q L L H D K G K S I Q D L R R R F F L H H L I A E I H T A.

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