Claims for Patent: 5,639,655
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Summary for Patent: 5,639,655
Title: | PML-RARA targeted ribozymes |
Abstract: | An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of promyelocytic leukemia. |
Inventor(s): | Thompson; James D. (Boulder, CO), Draper; Kenneth G. (Boulder, CO) |
Assignee: | Ribozyme Pharmaceuticals, Inc. (Boulder, CO) |
Application Number: | 08/233,030 |
Patent Claims: | 1. An enzymatic RNA molecule which specifically cleaves mRNA produced from the gene PML-RARA.
2. The enzymatic RNA molecule of claim 1, which cleaves target mRNA having a sequence selected from SEQ. ID. NOS. 1-62. 3. The enzymatic RNA molecule of claims 1 or 2, wherein said RNA molecule is in a hammerhead motif. 4. The enzymatic RNA molecule of claim 3, wherein said RNA molecule is in a hairpin, hepatitis Delta virus, group 1 intron, or RNAseP RNA motif. 5. The enzymatic RNA molecule of claim 3, wherein said ribozyme comprises between 5 and 23 bases complementary to said mRNA. 6. The enzymatic RNA molecule of claim 5, wherein said ribozyme comprises between 10 and 18 bases complementary to said mRNA. 7. A mammalian cell including an enzymatic RNA molecule of claims 1 or 2, in vitro. 8. The cell of claim 7, wherein said cell is a human cell. 9. An expression vector including nucleic acid encoding the enzymatic RNA molecule of claims 1 or 2, in a manner which allows expression of that enzymatic RNA molecule within a mammalian cell in vitro. |
Details for Patent 5,639,655
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2014-06-17 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2014-06-17 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2014-06-17 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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