Claims for Patent: 5,622,854
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Summary for Patent: 5,622,854
Title: | Method and reagent for inhibiting T-cell leukemia virus replication |
Abstract: | An enzymatic RNA molecule which specifically cleaves RNA of HTLV-1. |
Inventor(s): | Draper; Kenneth G. (Solon, OH) |
Assignee: | Ribozyme Pharmaceuticals Inc. (Boulder, CO) |
Application Number: | 08/192,941 |
Patent Claims: | 1. An enzymatic RNA molecule which specifically cleaves RNA of HTLV-1.
2. The enzymatic RNA molecule of claim 1 which cleaves RNA in the tax, rex, and pro gene regions. 3. The enzymatic RNA molecule of claim 1 which cleaves RNA in the 5'-LTR and 3'-LTR regions. 4. The enzymatic RNA molecule of claim 1 wherein said RNA molecule is in a hammerhead motif. 5. The enzymatic RNA molecule of claim 1 wherein said RNA molecule is in a hairpin, hepatitis Delta virus, group 1 intron, or RNaseP RNA motif. 6. The enzymatic RNA molecule of claim 1 which specifically cleaves a sequence comprising any of SEQ. ID. NOS. 1-25, wherein said enzymatic RNA molecule is in a hammerhead or hepatitis Delta virus motif. 7. The enzymatic RNA of any of claims 1, 2-6 wherein said ribozyme comprises between 5 and 23 bases complementary to the RNA of said gene or region. 8. The enzymatic RNA of any of claim 7 wherein said ribozyme comprises between 10 and 18 bases complementary to the RNA of said gene or region. 9. A mammalian cell including an enzymatic RNA molecule of any of claims 1, 2-6 in vitro. 10. The cell of claim 9, wherein said cell is a human cell. 11. An expression vector including a nucleic acid encoding the enzymatic RNA molecule of any of claims 1, 2-6, in a manner which allows expression of that enzymatic RNA molecule within a mammalian cell, in vitro. |
Details for Patent 5,622,854
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2014-04-22 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2014-04-22 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2014-04-22 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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