You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 23, 2024

Claims for Patent: 5,620,896

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 5,620,896

Title:	DNA vaccines against rotavirus infections
Abstract:	This invention relates to methods of eliciting an immune response and/or protective immunity in a vertebrate by introducing into the vertebrate a DNA vaccine which consists essentially of DNA encoding an antigen or antigens, e.g., capsid proteins or polypeptides, of rotavirus. The uptake of the DNA vaccine by a host vertebrate results in the expression of the capsid protein, thereby eliciting humoral or cell-mediated immune responses, or both, which can provide protection against infection and/or prevent clinically significant rotavirus-caused disease. In addition, the invention demonstrates that an internal vital antigen provides protective immunity in a host. The host can be any vertebrate, including birds, piglets, and humans.
Inventor(s):	Herrmann; John E. (Northborough, MA), Robinson; Harriet L. (Southborough, MA), Fynan; Ellen F. (Sterling, MA)
Assignee:	University of Massachusetts Medical Center (Worcester, MA)
Application Number:	08/426,169
Patent Claims:	1. A plasmid vector comprising (1) a cytomegalovirus intron A transcriptional regulatory sequence and (2) cytomegalovirus enhancer and promoter sequences operably linked to a nucleotide sequence encoding a rotavirus polypeptide selected from the group consisting of VP4, VP6 and VP7, wherein said rotavirus polypeptide is expressed in a cell of a mammal innoculated with said plasmid vector. 2. A plasmid vector of claim 1, wherein said cytomegalovirus promoter sequence further comprises the cytomegalovirus immediate-early promoter sequence. 3. A plasmid vector of claim 1, wherein said rotavirus polypeptide is VP4. 4. A plasmid vector of claim 1, wherein said rotavirus polypeptide is VP6. 5. A plasmid vector of claim 1, wherein said rotavirus polypeptide is VP7.

Details for Patent 5,620,896

Glossary

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2014-04-15
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2014-04-15
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2014-04-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.