You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 28, 2024

Claims for Patent: 5,612,215


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 5,612,215
Title: Stromelysin targeted ribozymes
Abstract:An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an arthritic condition.
Inventor(s): Draper; Kenneth G. (Boulder, CO), Pavco; Pamela (Layfayette, CO), McSwiggen; James (Boulder, CO), Gustofson; John (Boulder, CO), Stinchcomb; Dan T. (Boulder, CO)
Assignee: Ribozyme Pharmaceuticals, Inc. (Boulder, CO)
Application Number:08/390,850
Patent Claims:1. An enzymatic RNA molecule which specifically cleaves stromelysin RNA.

2. The enzymatic RNA molecule of claim 1, which specifically cleaves target RNA having a sequence selected from a group consisting of SEQ. ID. NOS. 1, 3-27, 29-359, wherein said enzymatic RNA molecule is in a hammerhead motif.

3. An enzymatic RNA molecule of claim 1, which specifically cleaves target mRNA having a sequence selected from SEQ. ID. NOS. 360-367 and 1054-1080 wherein said enzymatic RNA molecule is in a hairpin motif.

4. The enzymatic RNA molecule of claim 1, which specifically cleaves target mRNA having a sequence selected from SEQ. ID. NOS. 1-33, wherein said enzymatic RNA molecule is in a hepatitis delta virus motif.

5. The enzymatic RNA molecule of claim 2, which specifically cleaves target mRNA having a sequence selected from SEQ. ID. NOS. 34, 35, 37, 47, 54, 57, 61, 63, 64, 66, 76, 77, 79, 87, 88, 96, 97, 98, 99, 100, 107, 110, 121, 126, 128, 129, 133, 140, 146, 148, 151, 162, 170, 179, 188, 192, 194, 196, 199, 202, 203, 207, 208, 218, 220, 223, 224, 225, 227, 230, 232, 236, 240, 245, 246, 256, 259, 260, 269, 280, 281, 290, 302, 328, 335 and 353.

6. The enzymatic RNA molecule of claim 2, which specifically cleaves target mRNA having a sequence selected from SEQ. ID. NOS. 34, 35, 57, 125, 126, 127, 128, 129, 140, 162, 170, 179, 188, 223, 224, 236, 245, 246, 256, 259, 260, and 281.

7. The enzymatic RNA molecule of claim 2, which specifically cleaves target mRNA having a sequence selected from SEQ. ID. NOS. 35, 98, 202, 263, 272, and 292.

8. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hammerhead motif.

9. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hairpin, hepatitis Delta virus, group I intron, VS RNA,or RNAseP RNA motif.

10. The enzymatic RNA molecule of any of claims 4, 8, 9, 1, 2, or 3, wherein said enzymatic RNA molecule comprises between 5 and 23 bases complementary to said mRNA.

11. The enzymatic RNA molecule of any of claims 4, 8, 9, 1, 2 or 3, wherein said enzymatic RNA molecule comprises between 10 and 18 bases complementary to said mRNA.

12. The enzymatic RNA molecule of any of claims 4, 8, 9, 1, 2, or 3, wherein said enzymatic RNA molecule comprises between 30 and 45 bases complementary to said mRNA.

13. A mammalian cell including an enzymatic RNA molecule of any of claims 4, 8, 9, 1, 2 or 3 in vitro.

14. The cell of claim 13, wherein said cell is a human cell.

15. An expression vector including nucleic acid encoding the enzymatic nucleic acid molecule of any of claims 4, 8, 9, 1, 2 or 3, in a manner which allow expression of that enzymatic RNA molecule within a mammalian cell in vitro.

16. The enzymatic RNA molecule of any of claims 8 or 2, wherein said enzymatic RNA molecule comprises at least five ribose residues, and wherein said enzymatic RNA comprises a 2'-C-allyl modification at position No. 4 of said enzymatic RNA molecule, and wherein said enzymatic RNA molecule comprises at least ten 2'-O-methyl modifications.

17. The enzymatic RNA molecule of any of claims 8 or 2, wherein said enzymatic RNA molecule comprises at least five ribose residues, and wherein said enzymatic RNA comprises a 2'-amino modification at position No. 4 and/or at position No. 7 of said enzymatic RNA molecule, wherein said enzymatic RNA molecule comprises at least ten 2'-O-methyl modifications.

18. The enzymatic RNA molecule of any of claims 8 or 2, wherein said enzymatic RNA molecule comprises at least five ribose residues, and wherein said enzymatic RNA molecule comprises non-nucleotide substitution at position No. 4 and/or at position No. 7 of said enzymatic RNA molecule, wherein said enzymatic RNA molecule comprises at least ten 2'-O-methyl modifications.

19. The enzymatic RNA molecule of any of claims 8 or 2, wherein said enzymatic RNA molecule comprises at least five ribose residues, and wherein said enzymatic RNA molecule acid comprises 6-methyl uridine substitutions at position No. 4 and/or at position No. 7 of the said enzymatic RNA molecule, wherein said enzymatic RNA molecule comprises at least ten 2'-O-methyl modifications.

20. The enzymatic RNA molecule of any one of claims 4, 8, 9, 16, 17-19, 21-25, wherein said enzymatic RNA molecule comprises phosphorothioate linkages at at least three 5' terminal nucleotides.

21. The enzymatic RNA molecule of any of claims 8 or 2, wherein said hammerhead motif comprises a stem II region of length greater than or equal to two base-pairs.

22. The enzymatic RNA molecule of any of claims 9 or 3, wherein said hairpin motif comprises a stem IV region of length greater than or equal to two base-pairs.

23. The enzymatic RNA molecule of any one of claims 4, 8, 9, 1, 2 or 3, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted ribose moiety at its 3' end.

24. The enzymatic RNA molecule of any one of claims 4, 8, 9, 1, 2 or 3, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted thymidine moiety at its 3' end.

25. The enzymatic RNA molecule of any one of claims 4, 8, 9, 1, 2 or 3, wherein said enzymatic RNA molecule molecule comprises a 240 --3' linked inverted ribose or thymidine moiety at its 3' end.

26. The enzymatic RNA molecule of any one of claims 4, 8, 9, 1, 2 or 3, wherein said enzymatic RNA molecule comprises a 5'-end modification.

27. The enzymatic RNA molecule of any one of claims 4, 8, 9, 1, 2, or 3, wherein said enzymatic RNA molecule comprises at least on 2'-O-methyl sugar modification.

28. The enzymatic RNA molecule of any one of claims 4, 8, 9, 1, 2 or 3, wherein said enzymatic RNA molecule comprised at least one phosphorothioate group.

29. The enzymatic RNA molecule of claim 16, wherein said enzymatic RNA molecule comprises a stem II region of length greater than or equal to two base-pairs.

30. The enzymatic RNA molecule of claim 16, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted ribose moiety at its 3' end.

31. The enzymatic RNA molecule of claim 16, wherein said enzymatic RNA molecule further comprises a 3'--3' linked inverted thymidine moiety at its 3' end.

32. The enzymatic RNA molecule of any one of claim 16, wherein said enzymatic RNA molecule comprises a 240 --3' linked inverted ribose or thymidine moiety at its 3' end.

33. The enzymatic RNA molecule of claim 16, wherein said enzymatic RNA molecule comprises a 5'-end modification.

34. The enzymatic RNA molecule of claim 16, wherein said enzymatic RNA molecule comprises phosphorothioate linkages at at least three 5' terminal nucleotides.

35. The enzymatic RNA molecule of claims 17, wherein said enzymatic RNA molecule comprises a stem II region of greater than or equal to two base-pairs.

36. The enzymatic RNA molecule of claim 17, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted ribose moiety at its 3' end.

37. The enzymatic RNA molecule of claim 17, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted thymidine moiety at its 3' end.

38. The enzymatic RNA molecule of claim 17, wherein said enzymatic RNA molecule comprises a 240 --3' linked inverted ribose or thymidine moiety at its 3' end.

39. The enzymatic RNA molecule of claim 17, wherein said enzymatic RNA molecule comprises a 5'-end modification.

40. The enzymatic RNA molecule of claim 17, wherein said enzymatic RNA molecule comprises phosphorothioate linkages at at least three 5' terminal nucleotides.

41. The enzymatic RNA molecule of claim 18, wherein said enzymatic RNA molecule comprises a 5'-end modification.

42. The enzymatic RNA molecule of claim 18, wherein said enzymatic RNA molecule comprises a stem II region of length greater than or equal to two base-pairs.

43. The enzymatic RNA molecule of claim 18, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted ribose moiety at its 3' end.

44. The enzymatic RNA molecule of claim 18, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted thymidine moiety at its 3' end.

45. The enzymatic RNA molecule of any one of claim 18, wherein said enzymatic RNA molecule comprises a 240 --3' linked inverted ribose or thymidine moiety at its 3' end.

46. The enzymatic RNA molecule of claim 18, wherein said enzymatic RNA molecule comprise phosphorothioate linkages at at least three 5' terminal nucleotides.

47. The enzymatic RNA molecule of claim 18, wherein said enzymatic RNA molecule comprises a 5'-end modification.

48. The enzymatic RNA molecule of claim 19, wherein said enzymatic RNA molecule comprises a stem II region of length greater than or equal to two base-pairs.

49. The enzymatic RNA molecule of claim 19, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted ribose moiety at its 3' end.

50. The enzymatic RNA molecule of claim 19, wherein said enzymatic RNA molecule comprises a 3'--3' linked inverted thymidine moiety at its 3' end.

51. The enzymatic RNA molecule of any one of claim 19, wherein said enzymatic RNA molecule comprises a 240 --3' linked inverted ribose or thymidine moiety at its 3' end.

52. The enzymatic RNA molecule of claim 19, wherein said enzymatic RNA molecule comprises phosphorothioate linkages at at least three 5' terminal nucleotides.

53. The enzymatic RNA molecule of claim 2, wherein the enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 34.

54. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 35.

55. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 37.

56. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 47.

57. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 54.

58. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 57.

59. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 61.

60. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 63.

61. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 64.

62. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 66.

63. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 68.

64. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 76.

65. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 77.

66. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 79.

67. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 87.

68. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 88.

69. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 96.

70. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ-ID NO. 97.

71. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 98.

72. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO 99.

73. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO 100.

74. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO 107.

75. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO 110.

76. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO 121.

77. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO 125.

78. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 126.

79. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 127.

80. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 128.

81. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 129.

82. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 133.

83. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 140.

84. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 146.

85. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 148.

86. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 151.

87. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 162.

88. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 169.

89. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 170.

90. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 179.

91. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 188.

92. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 192.

93. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 193.

94. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 194.

95. The enzymatic RNA molecule of claim 2, wherein sad enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 196.

96. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 199.

97. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 202.

98. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 203.

99. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequences defined as SEQ ID NO. 207.

100. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 208.

101. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 218.

102. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 220.

103. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 223.

104. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 224.

105. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequences defined as SEQ ID NO. 225.

106. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 227.

107. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 230.

108. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 232.

109. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 236.

110. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 240.

111. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 245.

112. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 246.

113. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 256.

114. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 259.

115. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 260.

116. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 263.

117. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 269.

118. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 279.

119. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 280.

120. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 281.

121. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 290.

122. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 292.

123. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 302.

124. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 312.

125. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 328.

126. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 335.

127. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 336.

128. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 350.

129. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 353.

130. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 360.

131. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 361.

132. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 362.

133. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 363.

134. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 364.

135. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 365.

136. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 366.

137. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 367.

138. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1054.

139. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1055.

140. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1056.

141. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1057.

142. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1058.

143. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1059.

144. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1060.

145. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1061.

146. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1062.

147. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1063.

148. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1064.

149. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1065.

150. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1066.

151. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1067.

152. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1068.

153. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1069.

154. The enzymatic RNA molecule of claim 3, wheein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NOS. 1070.

155. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1071.

156. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1072.

157. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1073.

158. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1074.

159. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1075.

160. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1076.

161. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1077.

162. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1078.

163. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1079.

164. The enzymatic RNA molecule of claim 3, wherein said enzymatic RNA molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 1080.

165. The enzymatic RNA molecule of claim 8 wherein said enzymatic RNA molecule consists of any sequence selected from the group consisting of SEQ. ID NOS. 375-396.

166. The enzymatic RNA molecule of claim 9 wherein said enzymatic RNA molecule is in a hairpin motif and wherein said enzymatic RNA molecule consists of any sequence selected from the group consisting of SEQ. ID NOS. 1027-1053.

Details for Patent 5,612,215

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2014-03-18
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2014-03-18
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2014-03-18
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.