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Last Updated: April 23, 2024

Claims for Patent: 5,610,052

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Summary for Patent: 5,610,052

Title:	Enzymatic RNA with activity to ras
Abstract:	An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of colon carcinoma.
Inventor(s):	Thompson; James D. (Boulder, CO), Draper; Kenneth G. (Boulder, CO)
Assignee:	Ribozyme Pharmaceuticals Inc. (Boulder, CO)
Application Number:	07/936,110
Patent Claims:	1. The enzymatic RNA molecule which specifically cleaves K-ras RNA. 2. The enzymatic RNA molecule of claim 1 wherein said enzymatic RNA molecule is in a hairpin, hepatitis delta virus, group I intron or RNase P RNA motif. 3. The enzymatic RNA molecule of claim 1 which specifically cleaves the sequence shown as any of SEQ. ID. NOS. 1-26, wherein said enzymatic RNA molecule is in the hepatitis delta virus motif. 4. The enzymatic RNA molecule of claim 1 wherein said enzymatic RNA molecule is in a hammerhead motif. 5. The enzymatic RNA molecule of claim 1, which specifically cleaves the sequence shown as any of SEQ. ID. NOS. 1,4-15,17-23, 25 or 26--26, wherein said enzymatic RNA molecule is in the hammerhead motif. 6. The enzymatic RNA molecule of claim 1 wherein said enzymatic RNA molecule comprises between 5 and 23 bases complementary to said RNA. 7. The enzymatic RNA molecule of claim 1 wherein said enzymatic RNA molecule comprises between 10 and 18 bases complementary to said RNA. 8. The enzymatic RNA molecule of any one of claims 1-7 wherein the enzymatic RNA molecule comprises an 2'-O-methyl modification in at least one sugar moiety. 9. The enzymatic RNA molecule of any one of claim 1-7 or wherein said enzymatic RNA molecule comprises at least one phosphorothioate group. 10. A mammalian cell comprised of an enzymatic RNA molecule of any one of claims 1-7. 11. The cell of claim 10, wherein the cell is a human cell. 12. A mammalian cell comprised of a nucleic acid encoding the enzymatic RNA molecule of any one of claims 1-7 in a manner which allows expression of the enzymatic RNA molecule within the mammalian cell.

Details for Patent 5,610,052

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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