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Last Updated: March 29, 2024

Claims for Patent: 5,599,706


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Summary for Patent: 5,599,706
Title: Ribozymes targeted to apo(a) mRNA
Abstract:Enzymatic RNA molecules which cleave apo(a) mRNA.
Inventor(s): Stinchcomb; Dan T. (Boulder, CO), McSwiggen; James (Boulder, CO), Newton; Roger S. (Ann Arbor, MI), Ramharack; Randy (Ann Arbor, MI)
Assignee:
Application Number:08/311,760
Patent Claims:1. An enzymatic RNA molecule which specifically cleaves apo(a) mRNA.

2. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hammerhead motif.

3. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule specifically cleaves any one of the sequences defined as SEQ. ID. NOS. 7-85.

4. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hairpin, hepatitis delta virus, group I intron, Neurospora VS RNA or RNaseP RNA motif.

5. The enzymatic RNA molecule of claim 4, wherein said hairpin specifically cleaves any of the sequences defined as SEQ. ID. NOs. 165-241, 337-354, or 374-392.

6. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule comprises between 12 and 100 bases complementary to said mRNA.

7. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule comprises between 14 and 24 bases complementary to said mRNA.

8. The enzymatic RNA molecule of claim 2, wherein said enzymatic RNA molecule comprises any of sequences shown as SEQ. ID. Nos. 86-164, or 242-318.

9. The enzymatic RNA molecule of claim 4, wherein said hairpin comprises any of the sequences shown as SEQ. ID. NOs. 319-336, or 355-373.

10. The enzymatic RNA molecule of claim 2, wherein said hammerhead comprises a stem II region, and wherein said stem II is greater than or equal to 2 base pairs long.

11. The enzymatic RNA molecule of claim 4, wherein said hairpin comprises a stem IV region, and wherein said stem IV is greater than or equal to 2 base pairs long.

12. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said enzymatic RNA molecule comprises at least one sugar modification.

13. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said enzymatic RNA molecule comprises at least one base modification.

14. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said nucleic acid comprises at least one phosphate modification.

15. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said enzymatic RNA molecule comprises at least two sugar modifications, wherein one said modification is a 2'-O-methyl and the other said modification is a 2'-deoxy-2'-amino.

16. The enzymatic RNA molecule of any of claims 1, 3, 5, 2, 4, 6-8 and 9-11, wherein said enzymatic RNA molecule comprises at least two sugar modifications, wherein one said modification is a 2'-O-methyl and the other said modification is a 2'-C-allyl.

17. The enzymatic RNA molecule of claim 14, wherein said phosphate modification is a phosphorothioate.

18. A mammalian cell including an enzymatic nucleic acid molecule of any of claims 1, 3, 5, 2, 4, 6-8 in vitro.

19. The cell of claim 18, wherein said cell is a human cell.

20. An expression vector including a nucleic acid encoding an enzymatic RNA molecule or multiple enzymatic RNA molecules of claims 1, 3, 5, 2, 4, 6-8 in a manner which allows expression of that enzymatic RNA molecule(s) within a mammalian cell in vitro.

21. A mammalian cell in vitro including the expression vector of claim 20.

22. The cell of claim 12, wherein said cell is a human cell.

Details for Patent 5,599,706

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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