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Last Updated: September 18, 2021

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Claims for Patent: 5,589,331

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Summary for Patent: 5,589,331
Title: Method for detecting abnormal serotonergic function
Abstract:A method of detecting abnormal serotonergic function in an impulsive human subject is disclosed. The method comprises detecting an L allele of a gene encoding tryptophan hydroxylase. The invention also includes an isolated nucleic acid having a sequence specific to an L allele of a gene encoding tryptophan hydroxylase. The nucleic acid may migrate in a denaturing gel at the same rate as a second nucleic acid specific to a corresponding region of a U allele of a gene encoding tryptophan hydroxylase, and migrate in a nondenaturing gel at a rate about 1.02 times the migration rate of the second nucleic acid.
Inventor(s): Nielsen; David A. (Kensington, MD), Goldman; David (Potomac, MD), Linnoila; Markku (Bethesda, MD), Virkkunen; Matti (Helsinki, FI)
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Application Number:08/125,628
Patent Claims:1. A method of detecting abnormal serotonergic function in an impulsive human subject, the method comprising:

providing a nucleic acid sample from the human subject;

detecting the presence or absence of an L allele of the gene encoding tryptophan hydroxylase in the sample, wherein detecting the presence of the L allele detects abnormal serotonergic function in the impulsive human subject.

2. The method of claim 1, wherein the L allele is in a homozygous state.

3. The method of claim 1 wherein the L allele is detected using a polymerase chain reaction.

4. The method of claim 3 wherein the polymerase chain reaction uses primers that hybridize to the same nucleic acid sequence as an oligonucleotide selected from the group that consists of:

HTHSSCP4: 5'-TTCAGATCCCTTCTATACCCCAGAG-3' (Seq. ID No.:3)

HTHSSCP5: 5'-GGACATGACCTAAGAGTTCATGGCA-3' (Seq. ID No.:4).

5. The method of claim 1 wherein the L allele is detected by single strand conformation polymorphism analysis.

6. The method of claim 1 wherein the L allele is associated with a polymorphism within an intron of the gene encoding tryptophan hydroxylase.

7. The method of claim 6 wherein the intron corresponds to intron 7 of the mouse gene encoding tryptophan hydroxylase.

8. The method of claim 1 wherein the abnormal serotonergic function is suicidal behavior.

9. The method of claim 7 wherein the polymorphism is correlated with suicidal behavior.

10. An isolated nucleic acid consisting of a subsequence of the L allele of the gene encoding tryptophan hydroxylase, wherein the subsequence is SEQ. ID No:8.

11. The nucleic acid of claim 10 wherein the nucleic acid is obtained by polymerase chain reaction amplification of a nucleic acid sample from an impulsive subject.

12. A nucleic acid of claim 10 wherein the subsequence of the L allele comprises an intron.

13. A nucleic acid of claim 12 wherein the intron corresponds to intron 7 of the mouse gene encoding tryptophan hydroxylase.

Details for Patent 5,589,331

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ⤷  Free Forever Trial The United States of America as represented by the Department of Health (Washington, DC) 2013-12-31 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ⤷  Free Forever Trial The United States of America as represented by the Department of Health (Washington, DC) 2013-12-31 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ⤷  Free Forever Trial The United States of America as represented by the Department of Health (Washington, DC) 2013-12-31 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 5,589,331

Country Patent Number Estimated Expiration
Australia 4033793 ⤷  Free Forever Trial
Australia 682002 ⤷  Free Forever Trial
Canada 2130904 ⤷  Free Forever Trial
European Patent Office 0637341 ⤷  Free Forever Trial
Japan H07507206 ⤷  Free Forever Trial
World Intellectual Property Organization (WIPO) 9322458 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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