Claims for Patent: 5,563,132

Summary for Patent: 5,563,132

Title:	Two-step cancer treatment method
Abstract:	A two-step cancer treatment method consisting of the initial administration of a cancer-localizing peroxide-reactive metal-ion containing compound, and then administering a peroxide compound to the patient after allowing sufficient time for the localization to the cancer of the metal-ion containing compound to occur. The product of the chemical reaction between the cancer-localizing metal-ion containing compound, and the peroxide compound is an oxidant species which acts to destroy the cancer.
Inventor(s):	Bodaness; Richard S. (Bethesda, MD)
Assignee:
Application Number:	08/263,186
Patent Claims:	1. A method for the destruction of tissue comprising in sequence: a. administering to a patient a peroxide reactive, metal ion containing compound capable of localizing to tissue to be destroyed, b. allowing sufficient time for localization of said compound to said tissue to occur, and c. administering to said patient a peroxide compound capable of reacting with said metal ion containing compound to generate a reaction product capable of destroying said tissue, whereby the product of the reaction between said peroxide compound and said tissue localizing metal ion containing compound results in said destruction of said tissue. 2. The method of claim 1 wherein said tissue to be destroyed is a cancer. 3. The method of claim 1 wherein said metal ion is selected from the group consisting of copper, iron, nickel, manganese, cobalt, vanadium, chromium, silver, rhodium, ruthenium, technetium, molybdenum, niobium, zirconium, platinum, tin, lead, hafnium, tantalum, tungsten, rhenium, titanium, osmium, mercury, cerium, samarium, europium, and ytterbium. 4. The method of claim 1 wherein said peroxide is selected from the group consisting of hydrogen peroxide, organic peroxides, inorganic peroxides, peroxide complexes, peroxide salts, and superoxides. 5. The method of claim 1 wherein said metal ion is selected from the group consisting of peroxide reactive metal ions. 6. The method of claim 1 wherein said metal ion containing compound is selected from the group consisting of a metal ion incorporated into porphyrins, porphyrin derivatives, porphyrin like compounds, hematoporphyrins, etioporphyrins, protoporphyrins, uroporphyrins, mesoporphyrins, coproporphyrins, hematoporphyrin derivative, porphins, chlorins, phorbins, bacteriochlorins, porphyrinogens, phlorins, purpurins, rhodins, pheophorbides, erythrins, pheophyrins, pheophytins, phthalocyanines, phthalocyanine like compounds, verdins, corrins, corroles, corphins, sapphyrins, and derivatives thereof. 7. The method of claim 6 wherein said metal ion containing compound includes an antibody which localizes to said tissue to be destroyed. 8. The method of claim 1 wherein said metal ion containing compound includes an antibody which localizes to said tissue to be destroyed. 9. The method of claim 1 wherein said peroxide compound includes an antibody which localizes to said tissue to be destroyed. 10. The method of claim 1 wherein said metal ion containing compound includes an antibody which localizes to said tissue to be destroyed and said peroxide compound includes an antibody which localizes to said tissue to be destroyed. 11. The method of claim 10 wherein said antibody included in said peroxide compound is identical to said antibody included in said metal ion containing compound. 12. The method of claim 10 wherein said antibody included in said peroxide compound is different from said antibody included in said metal ion containing compound. 13. The method of claim 1 wherein said metal ion containing compound includes an antibody which localizes to said tissue to be destroyed, and said peroxide compound includes an antibody which localizes to said antibody included in said metal ion containing compound. 14. The method of claim 1 wherein said metal ion containing compound is selected from the group consisting of heme, hemin, hematin, microperoxidase, and compounds which contain heme, hemin, hematin, or microperoxidase. 15. The method of claim 1 wherein said metal ion containing compound localizes to a membrane of said tissue to be destroyed. 16. The method of claim 1 wherein said peroxide compound is formed in vivo from a peroxide generating compound. 17. The method of claim 1 wherein said tissue localizing metal ion containing compound is administered intravenously, intraarterially, intralesionally, topically, orally, or intracavitarily. 18. The method of claim 1 wherein said peroxide compound is administered intravenously, intraarterially, intralesionally, topically, orally, or intracavitarily. 19. The method of claim 1 wherein said metal ion containing compound and said peroxide compound are administered intravenously, intraarterially, intralesionally, topically, orally, or intracavitarily. 20. The method of claim 1 wherein said peroxide compound is produced endogenously from peroxide generating cells. 21. The method of claim 1 wherein said metal ion containing tissue localizing compound is initially free from metal ions when said compound is administered and wherein metal ions are subsequently incorporated into said compound in vivo. 22. The method of claim 1 wherein said tissue to be destroyed is an antigen. 23. A method for the treatment of cancer with cancer destroying oxidant species, which comprises: administering a peroxide reactive metal ion containing compound which will localize to cancer tissue; waiting a period of time sufficient for said metal ion containing compound to localize to said cancer tissue; and subsequently administering a peroxide compound which is capable of reacting with said metal ion containing compound which is localized to said cancer tissue, to generate said cancer destroying oxidant species. 24. A method for the treatment of disease comprising in sequence: a. administering a peroxide reactive, metal ion containing compound, said compound being capable of localizing to a component of said disease, b. allowing sufficient time for localization of said compound to said disease component to occur, and c. administering a peroxide compound, whereby the products of the reaction between said peroxide and said disease component localized metal ion containing compound, result in the destruction of said disease component and the treatment of said disease. 25. The method of claim 24 wherein said disease being treated is selected from the group consisting of cancer, precancer, noncancer, benign lesion, actinic keratosis, basal cell carcinoma, squamous cell carcinoma, seborrheic keratoses, psoriasis, pustular psoriasis, Reiter's disease, dermatitis herpetiformis, graft versus host disease, leukocytoclastic vasculitis, Sweet's syndrome, and diseases caused by viruses. 26. The method of claim 24 wherein said peroxide compound is produced endogenously from peroxide generating cells. 27. The method of claim 24 wherein said peroxide compound is formed in vivo from a peroxide generating compound.

Details for Patent 5,563,132

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	PANHEMATIN	hemin for injection	For Injection	101246	07/20/1983		2040-01-28