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Last Updated: March 28, 2024

Claims for Patent: 5,514,376


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Summary for Patent: 5,514,376
Title: Cell culture of hepatitis A virus
Abstract:Hepatitis A virus is attenuated in virulence by in vitro passage in susceptible cell cultures, without prior passage in a subhuman primate. This process results in a live, attenuated hepatitis A virus vaccine suitable for human disease prevention.
Inventor(s): Giesa; Paula A. (Lansdale, PA), Provost; Philip J. (Lansdale, PA), Hilleman; Maurice R. (Lafayette Hill, PA)
Assignee: Merck & Co., Inc. (Rayway, NJ)
Application Number:08/016,486
Patent Claims:1. A process for making a hepatitis A vaccine which comprises culturing an inoculum of HAV which has not been passaged through a non-human primate, wherein the culturing occurs in (i) primary, continuously cultivated, or transformed cells derived from kidney or liver tissue of non-human primate origin; and (ii) diploid lung fibroblast cells derived from human lung tissue.

2. A process for making a hepatitis A vaccine comprising:

a) culturing hepatitis A virus which has not been passaged through a non-human primate and which has been passaged in primary or continuously cultivated or transformed cells derived from kidney or liver tissue of non-human primate origin, or diploid fibroblast cells derived from human or non-human primate lung tissue;

b) harvesting the cultured HAV; and

c) inactivating the harvested HAV to make a vaccine.

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