Claims for Patent: 5,514,370

Summary for Patent: 5,514,370

Title:	High dosage topical forms of collagenase
Abstract:	This invention provides pharmaceutical compositions for topical application containing high concentrations of the enzyme collagenase in non-aqueous excipients. The invention also provides a particular excipient, dextran, which is especially useful for admixture with collagenase and which can also be used to advantage with other pharmaceutically active materials.
Inventor(s):	Stern; Harold (Baldwin Harbor, NY), Yee; David (Oceanside, NY)
Assignee:	Advance Biofactures of Curacao, N.V. (Brievengat, AN)
Application Number:	08/335,261
Patent Claims:	1. A method of treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition consisting essentially of an intimate physical admixture of a non-aqueous excipient and at least about 1,500 ABC units of collagenase per gram of excipient. 2. A method according to claim 1, wherein the composition is in the form of an ointment. 3. A method according to claim 2, wherein the excipient is petrolatum. 4. A method according to claim 2, wherein the composition contains from about 1,500 to about 5,000 ABC units of collagenase per gram of excipient. 5. A method according to claim 1, wherein the excipient is a dry powder. 6. A method according to claim 5, wherein the excipient is lactose. 7. A method according to claim 5, wherein the excipient is a mixture of polymyxin B sulfate and bacitracin in powder form. 8. A method according to claim 5, wherein the composition contains from about 2,500 to about 10,000 ABC units of collagenase per gram of excipient. 9. A method of treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition consisting essentially of a dry powdered intimate physical admixture of dextran as excipient and in excess of 5,000 ABC units of collagenase per gram of dextran. 10. A method according to claim 5, wherein the composition contains at least about 8,000 ABC units of collagenase per gram of excipient. 11. A method according to claim 1, wherein the composition also contains an antibiotic or antiseptic. 12. A method according to claim 1, wherein the condition is a burn. 13. A method according to claim 1, wherein the condition is a decubitus ulcer. 14. A method of treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition comprising an intimate physical admixture of a non-aqueous excipient and at least about 1,500 ABC units of collagenase per gram of excipient, said collagenase not being bound to the excipient by an added chemical binding agent. 15. A method according to claim 14, wherein the composition is in the form of an ointment. 16. A method according to claim 15, wherein the excipient is petrolatum. 17. A method according to claim 14, wherein the excipient is a dry powder. 18. A method according to claim 17, wherein the excipient is lactose. 19. A method according to claim 17, wherein the excipient is a mixture of polymyxin B sulfate and bacitracin in powder form. 20. A method according to claim 17, wherein the excipient is dextran. 21. A method according to claim 14, wherein the condition is a burn. 22. A method according to claim 14, wherein the condition is a decubitus ulcer. 23. A method for treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition comprising a dry powdered intimate physical admixture of water-soluble dextran and from about 0.01 to about 30 weight per cent of a pharmaceutical suited for topical application, said pharmaceutical not being bound to the dextran by an added chemical binding agent. 24. A method according to claim 23, wherein said pharmaceutical is collagenase in an amount from about 100 to about 10,000 ABC units per gram of dextran. 25. A method according to claim 23, wherein said pharmaceutical is an enzyme. 26. A method according to claim 23, wherein said pharmaceutical is an antibiotic. 27. A method for treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition consisting essentially of a dry powdered intimate physical admixture of water-soluble dextran and from about 0.01 to about 30 weight per cent of a pharmaceutical suited for topical application. 28. A method according to claim 27, wherein said pharmaceutical is collagenase in an amount from about 100 to about 10,000 ABC units per gram of dextran. 29. A method according to claim 27, wherein said pharmaceutical is an enzyme. 30. A method according to claim 27, wherein said pharmaceutical is an antibiotic.

Details for Patent 5,514,370

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2011-11-20