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Last Updated: March 29, 2024

Claims for Patent: 5,482,706


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Summary for Patent: 5,482,706
Title: Transmucosal therapeutic composition
Abstract:A transmucosal therapeutic composition comprising a physiologically active peptide or protein and a cytidine nucleotide derivative is described. The above composition results in a satisfactory transmucosal absorption of physiologically active peptides or proteins which are otherwise hardly absorbed from the mucosa. Since it allows self-administration to the mucosa, such as the nasal, vaginal or digestive tract mucosa, in lieu of injection which causes pain, the invention is of great utility as a pharmaceutical dosage form for physiologically active peptides or proteins which must be administered over a protracted time.
Inventor(s): Igari; Yasutaka (Kobe, JP), Yamada; Minoru (Kawanishi, JP), Taketomi; Shigehisa (Ikeda, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/049,402
Patent Claims:1. A transmucosal therapeutic composition comprising a physiologically active peptide or protein and an absorption promoting amount of cytidine nucleotide derivative;

wherein the cytidine nucleotide derivative is a cytidine mono-, di- or triphosphate, the oxygen atom of the phosphoric acid moiety is replaced by sulfur or nitrogen, and the phosphoric acid moiety has a substituent selected from a lower alkyl, a lower alkoxy or an amide group.

2. A composition according to claim 1, wherein the physiologically active peptide or protein is an antibiotic, a hematopoietic, an antiinfective agent, an antidementia agent, an antiviral agent, an antitumoral agent, an antipyretic, an analgesic, an antiinflammatory agent, an antiulcer agent, an antiallergic agent, an antidepressant, a psychotropic agent, a cardiotonic, an antiarrythmic agent, a vasodilator, an antihypertensive agent, an antidiabetic agent, an anticoagulant, a cholesterol lowering agent, a therapeutic agent for osteoporosis, a hormone or a vaccine.

3. A method for preventing or treating osteoporosis which comprises administering the composition according to claim 2 to a postmenopausal woman through a mucosal membrane, wherein the physiologically active peptide or protein is a therapeutic agent for osteoporosis.

4. A composition according to claim 1, wherein the weight ratio of the physiologically active peptide or protein to the cytidine nucleotide derivative is 10,000:1 through 1:10,000 (w/w).

5. A composition according to claim 1, wherein the composition is a liquid dosage form which contains a cytidine nucleotide derivative in a concentration of 0.01 to 24% (w/v) in water.

6. A composition according to claim 1, wherein the physiologically active peptide or protein is a cytokine, a peptide hormone, a growth factor, a factor acting on the cardiovascular system, a factor acting on the central and peripheral nervous systems, a factor acting on humoral electrolytes and hemal organic substances, a factor acting on bone and skeleton, a factor acting on the gastrointestinal system, a factor acting on the immune system, a factor acting on the respiratory system, a factor acting on the genital organs or an enzyme.

7. A composition according to claim 6, wherein the cytokine is a lymphokine selected from the group consisting of interferons and interleukins.

8. A composition according to claim 7, wherein the cytokine is interferon .alpha..

9. A composition according to claim 6, wherein the peptide hormone is parathyroid hormone or an active fragment thereof, insulin, growth hormone, luteinizing hormone releasing hormone, adrenocorticotropic hormone, oxytocin or luteinizing hormone.

10. A composition according to claim 9, wherein the peptide hormone is insulin.

11. A composition according to claim 6, wherein the factor acting on bone and skeleton is parathyroid hormone or a parathyroid hormone active fragment thereof.

12. A composition according to claim 11, wherein said parathyroid hormone active fragment is a peptide having an amino acid sequence designated SEQ ID NO:1 or SEQ ID NO:2.

13. A composition according to claim 11, wherein parathyroid hormone active fragment is a peptide having an amino acid sequence consisting of the 34 amino acids of parathyroid hormone, starting from the N-terminus.

14. A transmucosal therapeutic composition comprising a physiologically active peptide or protein and a cytidine nucleotide derivative, wherein the composition is a liquid dosage form which contains a cytidine nucleotide derivative in a concentration of 0.01 to 24% (w/v) in water and is administered through nasal or vaginal mucosa.

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