Claims for Patent: 5,457,092

Summary for Patent: 5,457,092

Title:	Methods of promoting bone growth in mammals comprising administration of modified parathyroid hormone
Abstract:	pPTH, bPTH or hPTH is modified by deletions from the natural C- and/or N-terminus. The modified compounds are useful active ingredients in therapeutic compositions. The therapeutic compositions do not stimulate renal adenylate cyclase but, rather, effect chondrocyte proliferation, that is to say, they exhibit a mitogenic and bone-specific effect.
Inventor(s):	Schluter; Klaus-Dieter (Braunschweig, DE), Mayer; Hubert (Braunschweig, DE), Wingender; Edgar (Braunschweig, DE)
Assignee:	Gesellschaft fur Biotechnologische Forschung mbH (GBF) (Braunschweig, DE)
Application Number:	08/120,248
Patent Claims:	1. A method of promoting bone growth in a mammal, which comprises: administering systemically to the mammal an effective amount for mitogenesis, of a parathyroid hormone selected from the group consisting of: pPTH, bPTH and hPTH, each modified by deletion of the N-terminus and the C-terminus thereof and each comprising amino acid residues +28 to +34. 2. The method of claim 1 wherein the hormone selected is one of bPTH and hPTH. 3. The method of claim 1 wherein the hormone selected comprises amino acid residues +20 to +48. 4. The method of claim 1 wherein the hormone selected is bPTH comprising amino acid residues +3 to +34. 5. The method of claim 1 wherein the hormone selected is hPTH comprising amino acid residues +28 to +48.

Details for Patent 5,457,092

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2012-10-10