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Last Updated: April 25, 2024

Claims for Patent: 5,416,071

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Summary for Patent: 5,416,071

Title:	Water-soluble composition for sustained-release containing epo and hyaluronic acid
Abstract:	(1) A composition which comprises erythropoietin and hyaluronic acid shows a sustained-release of the medicine in a living body, and (2) A water-soluble composition which comprises (a) a pharmacologically active polypeptide secreted by an animal body or its derivative or a chemically synthesized pharmacologically active substance, (b) a water-soluble species of hyaluronic acid or its nontoxic salt and (c) a water-soluble protein injectable into body fluids without showing any substantial pharmacological activity brings about a prolonged action in vivo of a pharmacologically active substance. In addition, the composition can be administered using a small-gauge needle and thereby contributes ot relieving pain in patients.
Inventor(s):	Igari; Yasutaka (Hyogo, JP), Yamada; Minoru (Hyogo, JP), Ogawa; Yasuaki (Kyoto, JP)
Assignee:	Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:	07/909,160
Patent Claims:	1. A water-soluble sustained-release pharmaceutical composition for injection, which composition comprises an admixture of (1) erythropoietin, (2) an amount of hyaluronic acid or its nontoxic salt effective for the sustained-release of erythropoietin, the hyaluronic acid or its nontoxic salt having a molecular weight of 500,000 to 3,000,000, the weight ratio of erythropoietin to hyaluronic acid or its nontoxic salt being in the range of about 0.0001:1 to 10:1, and (3) a water-soluble protein selected from the group consisting of human serum albumin, human serum globulin, collagen and gelatin, the weight ratio of the water-soluble protein to hyaluronic acid or its nontoxic salt being in the range of about 0.001:1 to 100:1. 2. A composition in accordance with claim 1, which is lyophilized. 3. A composition in accordance with claim 1, wherein the water-soluble protein is human serum albumin.

Details for Patent 5,416,071

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2012-05-16
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2012-05-16
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2012-05-16
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978	⤷ Try a Trial	2012-05-16
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995	⤷ Try a Trial	2012-05-16
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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