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Last Updated: April 25, 2024

Claims for Patent: 5,359,032

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Summary for Patent: 5,359,032

Title:	Interkeukin-1 inhibitor
Abstract:	This invention relates to interleukin inhibitors (IL-1 INHs) that selectively inhibit interleukin 1 activity. The invention also relates to processes for purifying such IL-1 INHs from urine and for producing such IL-1 INHs by hosts transformed with recombinant DNA molecules comprising DNA sequences encoding the inhibitors, and to methods of treatment and compositions characterized by such IL-1 INHs. These methods and agents are useful in immunosuppressive and anti-inflammatory applications and therapies.
Inventor(s):	Dayer; Jean M. (Geneva, CH), Seckinger; Philippe L. (Carouge, CH), Mazzei; Gonzalo J. (Geneva, CH), Shaw; Alan R. (Geneva, CH)
Assignee:	Biogen Inc. (Cambridge, MA)
Application Number:	07/985,506
Patent Claims:	1. A substantially pure IL-1 INH, migrating as a single band on SDS/PAGE and substantially free of apolipoprotein Al and retinol binding protein, the IL-1 INH being characterized by an inhibitory activity to (1) the LAF activity of IL-1 (2) the MCF activity of IL-1, (3) the IL-1 mediated fibroblast proliferation, and (4)the IL-1 binding to IL-1 receptors, and non-inhibitory activity to the TNF.alpha. mediated production of PGE.sub.2 and collagenase, wherein the IL-1 INH has a specific activity of at least 1.2.times.10.sup.3 U/mg in an IL-1 mediated IL-2 production assay. 2. The IL-1 INH according to claim 1 wherein IL-1 INH is further characterized by an inhibitory activity to IL-1-mediated production of IL-2. 3. The IL-1 INH according to claim 1, wherein the IL-1 INH specifically binds to IL-1 receptors on target cells. 4. The IL-1 INH according to claim 1 wherein the IL-1 INH has a molecular weight of about 25,000 daltons on SDS PAGE. 5. The IL-1 INH according to claim 4, wherein the IL-1 INH has an isoelectric point of 4.7 by chromatofocussing. 6. The IL-1 INH according to any one of claims 1-5 wherein the IL-INH is substantially free from other proteins. 7. The IL-1 INH according to claim 1 wherein the IL-1 INH has a specific activity of at least 1.2.times.10.sup.3 U/mg in an EL-4/CTLL assay. 8. The IL-1 INH according to claim 1, wherein the IL-1 INH has a specific activity of at least 3.8.times.10.sup.4 U/mg in an IL-1 receptor binding assay. 9. The IL-1 INH according to claim 1, wherein the IL-1 INH has a specific activity of at least 6.2.times.10.sup.4 U/mg in an IL-1/LAF assay. 10. The IL-1 INH according to claim 1, wherein the IL-1 INH has a specific activity of at least 3.5.times.10.sup.4 U/mg in an EL-4/CTLL assay. 11. The IL-1 INH according to claim 1, wherein the IL-1 INH has a specific activity of at least 3.0.times.10.sup.4 U/mg in an IL-1/MCF assay. 12. A pharmaceutical composition comprising a therapeutically effective amount of an IL-1 INH according to any one of claims 1 to 5 or 7-11 in a pharmaceutically acceptable vehicle.

Details for Patent 5,359,032

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2011-10-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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