Claims for Patent: 5,334,504
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Summary for Patent: 5,334,504
Title: | In vitro assay for detecting cell-mediated immune responses |
Abstract: | An in vitro method of detecting a cell-mediated immune response to a specific antigen, comprising incubating a whole blood sample with the specific antigen and detecting the presence of gamma interferon released by sensitized lymphocytes in the whole blood sample as an indication of a cell-mediated immune response to the specific antigen. |
Inventor(s): | Wood; Paul R. (Lower Templestowe, AU), Corner; Leigh A. (Romsey, AU) |
Assignee: | Commonwealth Scientific & Industrial Research Organisation (Campbell, AU) |
Application Number: | 08/124,439 |
Patent Claims: | 1. An in vitro method of detecting a cell-mediated immune response to a specific antigen in a human or animal, which comprises the steps of:
(i) incubating a whole blood sample from the human or animal with the specific antigen; and (ii) detecting the presence of gamma interferon (.gamma.IFN) released by sensitized lymphocytes in said whole blood sample to indicate a cell-mediated immune response to said specific antigen. 2. A method according to claim 1, wherein said step of detecting the presence of gamma interferon is an immunoassay for gamma interferon. 3. A method according to claim 2, wherein said immunoassay is an enzyme-linked immunosorbent assay (ELISA) or a radio-immunoassay (RIA) for gamma interferon. 4. A method according to claim 1, for the detection of M.bovis infections in cattle, wherein said specific antigen is the M.bovis antigen, tuberculin purified protein derivative (PPD). 5. A method according to claim 1 wherein said specific antigen is an antigen of Mycobacterium bovis, Mycobacterium paratuberculosis or Mycobacterium tuberculosis. 6. A method according to claim 2 wherein said specific antigen is an antigen of Mycobacterium bovis, Mycobacterium paratuberculosis or Mycobacterium tuberculosis. 7. A method according to claim 3 wherein said specific antigen is an antigen of Mycobacterium bovis, Mycobacterium paratuberculosis or Mycobacterium tuberculosis. |
Details for Patent 5,334,504
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Par Pharmaceutical Companies, Inc. | APLISOL | tuberculin, purified protein derivative | Injection | 103782 | 04/20/1998 | ⤷ Try a Trial | 2011-08-02 |
Sanofi Pasteur Limited | TUBERSOL | tuberculin, purified protein derivative | Injection | 103941 | 02/24/2000 | ⤷ Try a Trial | 2011-08-02 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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