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Last Updated: March 28, 2024

Claims for Patent: 5,334,504


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Summary for Patent: 5,334,504
Title: In vitro assay for detecting cell-mediated immune responses
Abstract:An in vitro method of detecting a cell-mediated immune response to a specific antigen, comprising incubating a whole blood sample with the specific antigen and detecting the presence of gamma interferon released by sensitized lymphocytes in the whole blood sample as an indication of a cell-mediated immune response to the specific antigen.
Inventor(s): Wood; Paul R. (Lower Templestowe, AU), Corner; Leigh A. (Romsey, AU)
Assignee: Commonwealth Scientific & Industrial Research Organisation (Campbell, AU)
Application Number:08/124,439
Patent Claims:1. An in vitro method of detecting a cell-mediated immune response to a specific antigen in a human or animal, which comprises the steps of:

(i) incubating a whole blood sample from the human or animal with the specific antigen; and

(ii) detecting the presence of gamma interferon (.gamma.IFN) released by sensitized lymphocytes in said whole blood sample to indicate a cell-mediated immune response to said specific antigen.

2. A method according to claim 1, wherein said step of detecting the presence of gamma interferon is an immunoassay for gamma interferon.

3. A method according to claim 2, wherein said immunoassay is an enzyme-linked immunosorbent assay (ELISA) or a radio-immunoassay (RIA) for gamma interferon.

4. A method according to claim 1, for the detection of M.bovis infections in cattle, wherein said specific antigen is the M.bovis antigen, tuberculin purified protein derivative (PPD).

5. A method according to claim 1 wherein said specific antigen is an antigen of Mycobacterium bovis, Mycobacterium paratuberculosis or Mycobacterium tuberculosis.

6. A method according to claim 2 wherein said specific antigen is an antigen of Mycobacterium bovis, Mycobacterium paratuberculosis or Mycobacterium tuberculosis.

7. A method according to claim 3 wherein said specific antigen is an antigen of Mycobacterium bovis, Mycobacterium paratuberculosis or Mycobacterium tuberculosis.

Details for Patent 5,334,504

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Par Pharmaceutical Companies, Inc. APLISOL tuberculin, purified protein derivative Injection 103782 04/20/1998 ⤷  Try a Trial 2011-08-02
Sanofi Pasteur Limited TUBERSOL tuberculin, purified protein derivative Injection 103941 02/24/2000 ⤷  Try a Trial 2011-08-02
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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