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Last Updated: April 23, 2024

Claims for Patent: 5,308,614

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Summary for Patent: 5,308,614

Title:	Methods for the production of antibodies and induction of immune responses to tumor-associated gangliosides by immunization with ganglioside lactones
Abstract:	The present invention relates to an improved method for the production of antibodies to tumor-associated gangliosides using ganglioside lactones. The resulting antibodies are useful in the detection and treatment of tumors containing gangliosides. The present invention also relates to methods of treatment of tumors by active immunization using ganglioside lactones.
Inventor(s):	Hakomori; Sen-Itiroh (Mercr Island, WA)
Assignee:	The Biomembrane Institute (Seattle, WA)
Application Number:	07/996,509
Patent Claims:	1. A method for inducing an immune response to a tumor-associated ganglioside comprising administering to a subject a composition consisting essentially of: (a) an immunogenically effective amount of an isolated lactone of a tumor-associated ganglioside; and (b) a pharmaceutically acceptable carrier. 2. The method as claimed in claim 1, wherein said tumor-associated ganglioside is selected from the group consisting of GD.sub.3, GD.sub.2, sialyl Le.sup.a, sialyl Le.sup.X, sialyl difucosyl Le.sup.x, GM.sub.3, 6C ganglioside, G2 ganglioside, disialosyl Le.sup.a, monosialyl type 1 chain, disialosyl type 1 chain and fucosyl GM.sub.1. 3. The method as claimed in claim 1, wherein said immunogenic effective amount is about 2.0 to 5.0 .mu.adsorbed on about 20 to 100 .mu.g of carrier. 4. The method as claimed in claim 1, wherein said carrier is selected from the group consisting of Bacillus Calmette-Guerin (BCG), diptheria toxoid, and tetanus toxoid. 5. The method as claimed in claim 1, wherein said carrier is an artificial or natural membrane or vaccinia virus.

Details for Patent 5,308,614

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Teknika Llc	TICE BCG	bcg live	For Injection	102821	06/21/1989	⤷ Try a Trial	2011-05-03
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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