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Last Updated: March 29, 2024

Claims for Patent: 5,230,895


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Summary for Patent: 5,230,895
Title: Sustained released delivery system for use in the periodontal pocket
Abstract:An in vivo method is described for treating a subject for periodontal disease by placing a mixture of a glyceride composition and a therapeutic agent in the periodontal pocket of subject such that the therapeutic agent is released in a sustained manner. The glyceride composition is selected such that the mixture of the glyceride composition and the therapeutic agent is capable of forming a gel in the environment of the periodontal pocket. Also described is a sustained release delivery system comprising the mixture of the glyceride composition and therapeutic agent.
Inventor(s): Czarnecki; Ronald F. (Palm City, FL), Williams; David L. (Reading, MA)
Assignee: Copley Pharmaceutical Inc. (Canton, MA)
Application Number:07/517,566
Patent Claims:1. An in vivo method for treating a subject for periodontal disease comprising, placing a mixture of a glyceride composition and a therapeutic agent in the periodontal pocket of the subject such that the therapeutic agent is released in a sustained manner within the periodontal pocket, wherein the mixture of the glyceride composition and the therapeutic agent is capable of forming a gel in the environment of the periodontal pocket and conforming to the periodontal pocket of the subject.

2. A method as claimed in claim 1 wherein the glyceride composition comprises at least 75 percent monoglycerides having an iodine value of at least 20.

3. A method as claimed in claim 1 wherein the glyceride composition comprises at least 90 percent monoglycerides having an iodine value of at least 50.

4. A method as claimed in claim 1 wherein the glyceride composition contains monoglycerides have a iodine value of at least 90.

5. A method as claimed in claim 1 wherein the glyceride composition is a Myverol composition.

6. A method as claimed in claims 1 or 3 wherein the therapeutic agent is an agent selected from the group consisting of anti-inflammatory, anti-microbial, immune-suppressive, immune-stimulatory, desensitizing, odor-masking, local anesthetic, anti oxidant, oxidizing, and appropriate combinations thereof.

7. A method as claimed in claims 1 or 3 wherein the therapeutic agent is an anti-inflammatory agent.

8. A method as claimed in claim 7 wherein the anti-inflammatory agent is non steroidal.

9. A method as claimed in claim 8 wherein the anti-inflammatory agent is selected from a group consisting of flubiprofen and ibuprofen.

10. A method as claimed in claim 7 wherein the anti-inflammatory agent is steroidal.

11. A method as claimed in claim 6 wherein the therapeutic agent is an anti-microbial agent.

12. A method as claimed in claim 11 wherein the anti-microbial agent is selected from the group consisting of antibiotics, iodine solutions, mercurials, nitroimidazoles, sulfonamides, bisguanides and phenolics.

13. A method as claimed in claim 12 wherein the anti-microbial agent is an antibiotic.

14. A method as claimed in claim 13 wherein the antibiotic is selected from the group consisting of tetracycline, minocycline, doxycycline, vanomycin, erythromycin, penicillin, bacitracin, kanamycin, and neomycin.

15. A method as claimed in claim 13 wherein the antibiotic is selected from the group consisting of tetracycline, oxytetracycline, minocycline, and doxycycline.

16. A method as claimed in claim 15 wherein the antibiotic is tetracycline.

17. A method as claimed in claim 6 wherein the anti-infective agent is selected from the group consisting of metronidazole and chlorhexidine.

18. A method as claimed in claims 1 or 3 wherein the therapeutic agent has anti-collagenase activity.

19. A method as claimed in claims 1 or 3 wherein about 5 to about 40 percent by weight of therapeutic agent is mixed with the glyceride composition.

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