You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 5,194,257


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 5,194,257
Title: Kit and method for administration of bacillus calmette-guerin for the treatment of superficial bladder tumors
Abstract:Improved treatment of superficial bladder tumors through the administration by intravesical instillation of bacillus Calmette-Guerin is realized through the use of therapeutic composition comprising bacillus Calmette-Guerin (BCG) suspended in a 0.15 M sodium chloride solution containing a buffer to maintain the pH of the solution in the range 6.6 to 7.4, preferably 7.0. A kit and method are provided whereby such a composition may be employed to maximize intravesical attachment of BCG for improved efficacy.
Inventor(s): Ratliff; Timothy L. (St. Louis, MO), Hudson; M\'Liss A. (St. Louis, MO), Ritchey; Julie K. (St. Louis, MO)
Assignee: The Jewish Hospital of St. Louis (St. Louis, MO)
Application Number:07/619,222
Patent Claims:1. A kit for use in the in vivo treatment of superficial bladder tumors through the administration by intravesical instillation of bacillus Calmette-Guerin comprising:

(a) a dosage amount of bacillus Calmette-Guerin in lyophilized form; and

(b) a 0.15 M sodium chloride solution containing a buffer to maintain the pH of said solution within the range 6.6 to 7.4.

2. A kit as set forth in claim 1 wherein said sodium chloride solution is maintained at a pH of approximately 7.0.

3. A kit as set forth in claim 1 wherein said buffer is selected from the group consisting of phosphate, Tris (hydroxymethyl)aminomethane, N-tris[hydroxymethyl]-methyl-2-aminoethanesulfonic acid, N,N-bis[2-hydroxyethyl]-2-aminoethanesulfonic acid, 3-(N-morpholino)propanesulfonic acid, 3-(N-morpholino)-2-hydroxy-propanesulfonic acid, and N-[2-hydroxyethyl]piperazine-N[2-ethanesulfonic acid].

4. A method for the treatment of superficial bladder tumors in a mammal which comprises administering to said mammal a therapeutic composition comprising bacillus Calmette-Guerin suspended in a 0.15 M sodium chloride solution containing a buffer to maintain the pH of said solution in the range 6.6 to 7.4.

5. A method as set forth in claim 4 wherein said sodium chloride solution is maintained at a pH of approximately 7.0.

6. A method as set forth in claim 4 wherein said buffer is selected from the group consisting of phosphate, Tris (hydroxymethyl)aminomethane, N-tris[hydroxymethyl]methyl-2-aminoethanesulfonic acid, N,N-bis[2-hydroxyethyl]-2-aminoethanesulfonic acid, 3-(N-morpholino)propanesulfonic acid, 3-(N-morpholino)-2-hydroxy-propanesulfonic acid, and N-[2-hydroxyethyl]piperazine-N[2-ethanesulfonic acid].

7. A method as set forth in claim 4 wherein said treatment is continued for a period of approximately 2 hours.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.