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Last Updated: April 25, 2024

Claims for Patent: 5,190,861

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Summary for Patent: 5,190,861

Title:	Method for the diagnosis of rheumatoid arthritis
Abstract:	A method for diagnosing rheumatoid arthritis, which is characterized by enzyme-immunologically measuring the amount of collagenase inhibitor present in sera, plasmas or synovial fluids by way of a sandwich assay wherein two different monoclonal antibodies which specifically bind to different antigenic determinants of the collagenase inhibitor are used, and comparing the measured amount with that for normal subjects.
Inventor(s):	Hayakawa; Taro (Nagoya, JP), Kodama; Shuji (Takaoka, JP), Iwata; Kazushi (Takaoka, JP), Kishi; Junichi (Nagoya, JP), Yamashita; Kyoko (Nagoya, JP), Iwata; Hisashi (Nagoya, JP)
Assignee:	Fuji Yakuhin Kogyo Kabushiki Kaisha (Toyama, JP)
Application Number:	07/348,701
Patent Claims:	1. A method for diagnosing rheumatoid arthritis which comprises enzyme-immunologically measuring the amount of collagenase inhibitor present in sera, plasma or synovial fluid by means of a sandwich assay wherein two different monoclonal antibodies which specifically bind to different antigenic determinants of the collagenase inhibitor are used, wherein the first of said monoclonal antibodies is used for attachment of antigen to the solid phase and is an IgG-type antibody which is produced by a hybridoma having all of the identifying characteristics of the hybridoma deposited as BP-3469 and wherein the second of said monoclonal antibodies is enzyme conjugated and used to detect antigen bound by said first monoclonal antibody, said second antibody being produced by a hybridoma having all of the indentifying characteristics of the hybridoma deposited as BP-3468, and comparing the measured amount of collagenase inhibitor with that found in normal subjects.

Details for Patent 5,190,861

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2010-03-02
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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