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Last Updated: March 28, 2024

Claims for Patent: 5,160,483


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Summary for Patent: 5,160,483
Title: Fragment of TNF-.alpha. for promoting wound healing
Abstract:A method and composition for promoting the healing of an open wound, such as a fresh surgical incision, a decubitus ulcer, or a diabetes ulcer. The method includes applying to the wound a therapeutically effective amount of a composition comprising a protein fragment of tumor necrosis factor .alpha.(TNF-.alpha.) including amino acids 31 through 68 SEQ ID NO.: 1. The composition may be applied topically or injected locally into a wound or ulcer site. A preferred composition includes a carrier medium selected from sterile water, sterile saline, and albumin. Topical formulations are administered as sprays, gels, ointments or salves.
Inventor(s): Postlethwaite; Arnold E. (Eads, TN), Seyer; Jerome M. (Memphis, TN), Kang; Andrew H. (Memphis, TN)
Assignee: The University of Tennessee Research Corporation (Knoxville, TN)
Application Number:07/697,642
Patent Claims:1. A method for promoting the healing of a wound comprising applying to the wound a therapeutically effective dose of a composition consisting essentially of a protein fragment of tumor necrosis factor .alpha. (TNF-.alpha.) amino acids 31 through 68 SEQ ID No: 1.

2. The method of claim 1 wherein the composition is applied topically by direct contact with the wound.

3. The method of claim 2 wherein the wound is a fresh surgical incision.

4. The method of claim 2 wherein the wound is a decubitus ulcer.

5. The method of claim 2 wherein the wound is a diabetic ulcer.

6. The method of claim 1 wherein the composition further comprises a carrier medium selected from the group consisting of sterile water, sterile saline, and albumin.

7. The method of claim 1 including an initial step of preparing and purifying the protein fragment of TNF-.alpha. by recombinant nucleic acid techniques.

8. A composition for promoting the healing of wounds, the composition comprising:

a protein fragment of TNF-.alpha. including amino acids 31 through 68 SEQ ID No.:1; and

a carrier medium.

9. The composition of claim 8 wherein the protein fragment of TNF-.alpha. has the sequence SEQ ID No:1 ##STR2##

10. The composition of claim 8 wherein the carrier medium is selected from the group consisting of sterile water, sterile saline, and albumin.

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