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Last Updated: April 25, 2024

Claims for Patent: 5,147,783

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Summary for Patent: 5,147,783

Title:	Methods to screen for ovarian cancer and myocardial infarction
Abstract:	A monoclonal antibody against human manganese-superoxide dismutase characterized in that it is produced by a cell line which has been obtained by immunization of a mouse with human Mn-SOD and then fusion of lymphocytes obtained from the mouse with mouse myeloma cells, and has high specificity against human Mn-SOD; a method for producing a monoclonal antibody against human Mn-SOD having high specificity against human Mn-SOD, which comprises culturing the cell line obtained by immunization of a mouse with human Mn-SOD and then cell fusion of lymphocytes obtained from the mouse with mouse myeloma cells; a kit for assaying human Mn-SOD, comprising: (a) a monoclonal antibody having very high specific immuno-reactivity against human Mn-SOD; and (b) a reagent of a monoclonal antibody having very high specific immuno-reactivity against human Mn-SOD labelled with an enzyme (enzyme labelled antibody); a method for assaying human Mn-SOD use of the kit; a novel diagnostic method of human epithelial ovarian cancer, which comprises assaying the concentration of human Mn-SOD in a body fluid by use of the assay kit; and a novel diagnostic method of myocardial infarction, which comprises assaying the concentration of human Mn-SOD in a body fluid by use of the assay kit.
Inventor(s):	Uda; Taizo (Ube, JP), Itoh; Yukikatsu (Ube, JP), Kawaguchi; Tetsuo (Ube, JP), Hifumi; Emi (Ube, JP), Taniguchi; Naoyuki (Toyonaka, JP), Suzuki; Keiichiro (Takatsuki, JP), Ishikawa; Mutsuo (Asahikawa, JP), Noji; Shirou (Tokyo, JP)
Assignee:	Ube Industries, Ltd. (Ube, JP)
Application Number:	07/352,109
Patent Claims:	1. A method of screening for human epithelial ovarian cancer, which comprises (a) assaying for a concentration of human Mn-SOD in a body fluid by contacting the bodily fluid with a monoclonal antibody having a high specificity against human Mn-SOD, said monoclonal antibody not being reactive with any human albumin, human globulin, Cu and Zn-SOD, said monoclonal antibody being immobilized on a carrier, and (b) determining whether a concentration of 130 ng/ml or more of human Mn-SOD in a bodily fluid is present as an indication of the presence of epithelial ovarian cancer. 2. The method according to claim 1, wherein the monoclonal antibody is secreted from a hybridoma selected from the group consisting of FERM-BP 1606, FERM-BP 1607 and FERM-BP 1608. 3. A method of screening for myocardial infarction, which comprises (a) assaying for a concentration of human Mn-SOD in a body fluid by contacting the bodily fluid with a monoclonal antibody having a high specificity against human Mn-SOD, said monoclonal antibody not being reactive with any of human albumin, human globulin. Cu and Zn-SOD, said monoclonal antibody being immobilized on a carrier, and (b) determining whether a concentration of 150 ng/ml of more of human Mn-SOD in a bodily fluid is present as an indication of an occurrence of a myocardial infarction. 4. The method according to claim 3, wherein the monoclonal antibody is secreted from a hybridoma selected from the group consisting of FERM-BP 1606, FERM-BP 1607 and FERM-BP 1608.

Details for Patent 5,147,783

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2009-09-15
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2009-09-15
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2009-09-15
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978	⤷ Try a Trial	2009-09-15
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995	⤷ Try a Trial	2009-09-15
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	06/11/2003	⤷ Try a Trial	2009-09-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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