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Last Updated: March 28, 2024

Claims for Patent: 5,139,944


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Summary for Patent: 5,139,944
Title: Collagen-specific enzyme with platelet aggregation inhibition properties
Abstract:The collagenase is like tissue collagenases in that it cleaves collagen at a single site. The collagenase which has a molecular weight of about 50 k daltons, specifically inhibits collagen-induced platelet aggregation, with substantially no effect on platelet count or size, and may be used alone or together with another platelet aggregation inhibitor. The latter may also be a leech-derived biochemical, such as an apyrase, or an inhibitor of the release of platelet aggregation factor by leucocytes.
Inventor(s): Sawyer; Roy T. (Swansea, GB), Rigbi; Meir (Jerusalem, IL), Levy; Haim (Jerusalem, IL), Iraqi; Fuad (Jerusalem, IL)
Assignee: Biophram (UK) Limited (West Glamorgan, GB) Yissum Research Development Company of the Hebrew University of Jerusalem (Jerusalem, IL)
Application Number:07/647,652
Patent Claims:1. A substantially pure collagenase isolated from leech tissue or from leech secretion, said collagenase being capable of (a) causing hydrolytic scission of peptide bonds in the helical regions of undenatured collagen molecules, (b) causing only one cut per chain of said collagen molecules, and (c) digesting gelatin.

2. The collagenase of claim 1 wherein the collagenase is also capable of inhibiting collagen-induced platelet aggregation.

3. The collagenase of claim 2 wherein the molecular weight is from 45 to 55 kdaltons.

4. A method for isolating collagenase according to claim 1, which method comprises the steps of

(a) fractionating a fluid regurgitated by leeches by means of a gel fractionation; and

(b) collecting eluate fractions containing said collagenase.

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