➤ Get the DrugPatentWatch Daily Briefing

Get Daily Updates on Generic Entry, Litigation, Biosimilars, and more …

Serving leading biopharmaceutical companies globally:

Baxter
Mallinckrodt
Dow
McKinsey
Moodys
Merck

Last Updated: September 18, 2021

DrugPatentWatch Database Preview

Claims for Patent: 5,120,656

➤ Get the DrugPatentWatch Daily Briefing

« Back to Dashboard

Summary for Patent: 5,120,656
Title: Process for debriding bone
Abstract:Bone is enzymatically debrided prior to undergoing further processing which renders the bone suitable for osteoprosthetic use.
Inventor(s): O\'Leary; Robert K. (Spring Lake, NJ), Prewett; Annamarie B. (Fairhaven, NJ)
Assignee: Osteotech, Inc. (Shrewsbury, NJ)
Application Number:07/560,661
Patent Claims:1. A process for the debridement of harvested bone having its periosteum intact which comprises contacting, the periosteum with a solution of at least one collagen-digesting enzyme under enzyme activity-promoting conditions for a period of time sufficient to loosen the periosteum from the underlying bone surface and thereafter removing the enzymatically loosened periosteum from the bone.

2. The process of claim 1 wherein the collagen-digesting enzyme is selected from the group consisting of collagenase, stromelysin and mixtures thereof.

3. The process of claim 1 wherein the temperature of contacting ranges from about 20.degree. C. to about 70.degree. C.

4. The process of claim 1 wherein the temperature of contacting ranges from about 25.degree. to about 55.degree. C.

5. The process of claim 1 wherein the pH ranges from about 3 to 9.

6. The process of claim 1 wherein the contact time of the periosteum with the enzyme solution is at least about 30 minutes.

7. The process of claim 1 wherein the enzyme solution is a sterile physiological saline solution.

8. The process of claim 1 wherein the enzyme solution contains a permeation enhancer.

9. The process of claim 8 wherein the permeation enhancer is a surface active agent.

10. The process of claim 1 wherein the enzyme solution contains at least one member of the group consisting of antibiotic and disinfectant.

11. The process of claim 10 wherein the disinfectant is ethanol.

12. The process of claim 1 wherein the enzyme solution contains a permeation enhancer and at least one member of the group consisting of antibiotic and disinfectant.

13. The process of claim 1 wherein the enzyme solution contains an enzyme permeation enhancing amount of at least one enzyme permeation enhancing surface active agent and a disinfecting amount of ethanol.

14. The process of claim 1 wherein the enzymatically loosened periosteum is removed from the bone by the impact of a high velocity fluid stream directed against the periosteum.

15. The process of claim 14 wherein the high velocity fluid stream is water or physiological saline.

16. The process of claim 1 wherein removal of the enzymatically loosened periosteum from the bone is accompanied by exposure of the bone to sterilizing ultraviolet radiation.

17. The process of claim 15 wherein removal of the enzymatically loosened periosteum from the bone is accompanied by exposure of the bone to sterilizing ultraviolet radiation directed against the surface of the periosteum upon which the high velocity fluid stream impinges.

18. The process of claim 1 wherein the periosteum-containing bone is contacted with a solution of proteolytic enzyme before, during or following contact of the periosteum with the solution of collagen-digesting enzyme.

19. The process of claim 18 wherein the proteolytic enzyme is present in the solution of collagen-digesting enzyme.

20. The process of claim 18 wherein the collagen-digesting enzyme is collagenase.

21. The process of claim 19 wherein the collagen-digesting enzyme is collagenase.

Details for Patent 5,120,656

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Free Forever Trial Osteotech, Inc. (Shrewsbury, NJ) 2009-08-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Mallinckrodt
Medtronic
Dow
Boehringer Ingelheim
AstraZeneca
McKesson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.