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Last Updated: March 29, 2024

Claims for Patent: 5,102,663


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Summary for Patent: 5,102,663
Title: Vaccine for stimulating or enhancing production of antibodies against 9-O-acetyl GD3
Abstract:The present invention provides a vaccine for stimulating or enhancing in a subject to whom the vaccine is administered, production of antibodies directed against 9-O-acetyl GD3 ganglioside comprising an amount of purified 9-O-acetyl GD3 ganglioside effective to stimulate or enhance antibody production This invention was made with government support under Grant Numbers CA-40532 and CA-43971, National Cancer Institute, Department of Health and Human Services. Accordingly, the U.S. Government has certain rights in the invention.
Inventor(s): Livingston; Philip O. (New York, NY), Ritter; Gerd J. (New York, NY), Oettgen; Herbert F. (New Canaan, CT), Old; Lloyd J. (New York, NY)
Assignee: Sloan-Kettering Instutute for Cancer Research (New York, NY)
Application Number:07/259,182
Patent Claims:1. A composition for stimulating or enhancing in a subject to whom the composition is administered, production of antibodies against 9-O-acetyl GD3 ganglioside comprising an amount of a 9-O-acetyl GD3 ganglioside effective to stimulate or enhance antibody production in the subject and a pharmaceutically acceptable carrier.

2. A composition of claim 1 which additionally comprises an adjuvant.

3. A composition of claim 2, wherein the adjuvant is a microbial adjuvant.

4. A composition of claim 3, wherein the microbial adjuvant comprises Salmonella minnesota R595.

5. A composition of claim 3, wherein the microbial adjuvant comprises bacillus Calmette-Guerin.

6. A composition of claim 1, wherein the effective amount of 9-O-acetyl GD3 ganglioside comprises an amount between about 50 micrograms and about 300 micrograms.

7. A composition of claim 1, wherein the 9-O-acetyl GD3 ganglioside is purified from a biological source.

8. A composition of claim 7, wherein the biological source is a melanoma cell.

9. A composition of claim 7, wherein the biological source is milk.

10. A composition of claim 7, wherein the biological source is buttermilk.

11. A composition of claim 1, whick additionally comprises purified GM2 ganglioside.

12. A method for stimulating or enhancing in a subject production of antibodies against 9-O-acetyl GD3 ganglioside comprising administering to the subject an effective dose of a composition of claim 1.

13. A method of claim 12, wherein the 9-O-acetyl GD3 ganglioside is bound to a microbial adjuvant.

14. A method of claim 12, wherein the 9-O-acetyl GD3 ganglioside is bound to the microbial adjuvant by a hydrophobic bond between the lipid portion of the 9-O-acetyl GD3 ganglioside and the cell membrane of the microbial adjuvant.

15. A method of claim 12, wherein the microbial adjuvant is Salmonella minnesota R595 or bacillus Calmette-Guerin.

16. A method of claim 12, wherein an effective amount of cyclophosphamide is administered to the subject prior to administering the composition.

17. A method of claim 16, wherein the cyclophosphamide is administered between about 3 days and about 7 days prior to the administering the composition.

18. A method of claim 16, wherein the effective amount of cyclophosphamide is between about 1 mg/m.sup.2 and about 500 mg/m.sup.2.

19. A 9-O-acetyl GD3 ganglioside designated F2 characterized by the presence of a second acetyl group and the mass spectra shown in FIGS. 6A, 6B, and 6C.

20. A 9-O-acetyl GD3 ganglioside designated F3 characterized by the presence of 2 or more additional acetyl groups and recoverable from a mixture of acetylated derivatives of GD3 by a high pressure liquid chromatography.

21. A mixture of the 9-O-acetyl GD3 gangliosides F2 and F3.

22. A composition for stimulating or enhancing in a subject to whom the composition is administered, production of antibodies against 9-O-acetyl GD3 ganglioside comprising an amount of a 9-O-acetyl GD3 ganglioside of any of claims 38, 39 or 40 effective to stimulate or enhance antibody production in the subject and a pharmaceutically acceptable carrier.

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