Claims for Patent: 5,089,268

Summary for Patent: 5,089,268

Title:	Egg phosphatide lipid emulsions altered for a specific therapeutic fatty acid composition
Abstract:	A sterile lipid emulsion composition made from fish oil enriched egg phosphatides; a natural oil, an osmotic agent such as glycerin and purified water, optionally adjusted to a pH of between 8.5 and 10.5 with sodium hydroxide. This composition can be administered parenterally to a host mammal.
Inventor(s):	Katz; David P. (Flushing, NY)
Assignee:
Application Number:	07/642,143
Patent Claims:	1. In a sterile lipid emulsion for parenteral use, comprising: (a) from 1 to 30% by weight of a neutral lipid mixture of fatty acid triglycerides containing omega-3 fatty acids, omega-6 fatty acids, medium chain length triglycerides or mixtures thereof; (b) from 1 to 4% by weight of an egg yolk phosphatide emulsifier; (c) up to 2.25% by weight of an osmolality modifier; and (d) sterile water; the improvement, wherein the egg yolk phosphatide is derived from the eggs of chickens whose diets have been supplemented with fish oils which are rich in eicosapentaenoic acid, docosahexaenoic acid or mixtures thereof, said egg yolk phosphatide containing from 10 to 100% higher amounts of omega-3 fatty acids than egg yolk phosphatides derived from the eggs of chickens whose diets have not been so supplemented. 2. The sterile lipid emulsion of claim 1, wherein the neutral lipid mixture is derived from at least one natural oil selected from the group consisting of fish oil, butter oil, coconut oil, cottonseed oil, lard, olive oil, sesame seed oil, soya bean oil, safflower oil and sunflower oil. 3. The sterile lipid emulsion of claim 2, wherein the natural oil is soybean oil. 4. The sterile lipid emulsion of claim 1, wherein the egg yolk phosphatide emulsifier is derived from the eggs of chickens whose diets have been supplemented with at least one fish oil selected from the group consisting of herring, cod, halibut, tuna, sardine, salmon, anchovy or menhaden oils. 5. The sterile lipid emulsion of claim 1, whose pH has been adjusted with base to a pH of from 8.5 to 10.5. 6. The sterile lipid emulsion of claim 1, wherein said osmolality modifier is glycerin. 7. In a sterile lipid emulsion for parenteral use, comprising: (a) from 1 to 30% by weight of soybean oil; (b) from 1 to 4% by weight of finely divided particles of an egg yolk phosphatide emulsifier; (c) up to 2.25% by weight of glycerin as an osmolality modifier; (d) sterile water; and (e) a basic pH modifier in an amount sufficient to adjust the pH of the emulsion to a pH of from 8.5 to 10.5; the improvement, wherein the egg yolk phosphatide is derived from the eggs of chickens whose diets have been supplemented with at least one fish oil selected from the group consisting of herring, code, one or more of the fish oils derived from herring, cod, halibut, tuna, sardine, salmon, anchovy or menhaden oil, said egg yolk phosphatide containing from 10 to 100% higher amounts of omega-3 fatty acids than egg yolk phosphatides derived from the eggs of chickens whose diets have not been so supplemented. 8. The sterile lipid emulsion of claim 7, wherein the egg yolk phosphatide emulsifier particles are within the range of from 0.2 to 1.0 micron in size. 9. The sterile lipid emulsion of claim 7, containing: (a) 2% by weight soybean oil; (b) 2% by weight of the egg yolk phosphatide emulsifier; and (c) sodium hydroxide in an amount sufficient to adjust the pH of the emulsion to from 8.5 to 9.5.

Details for Patent 5,089,268

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2010-05-02