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Last Updated: April 25, 2024

Claims for Patent: 5,071,767

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Summary for Patent: 5,071,767

Title:	Process for the determination of fructosamine in body fluids and calibration solution
Abstract:	For the determination of fructosamine in body fluids a solution containing fructosamine and albumin is used as the standard solution for calibration which standard solution is essentially free of glucose and which has a pH between 5.0 and 6.0 and contains at least 10 mmol/l buffer.
Inventor(s):	Portenhauser; Rudolf (Tutzing, DE), Vogt; Bernd (Tutzing, DE)
Assignee:	Boehringer Mannheim GmbH (Mannheim, DE)
Application Number:	07/375,746
Patent Claims:	1. A process for the determination of fructosamine in body fluid comprising measuring a characteristic of the body fluid that is related to the amount of fructosamine in the body fluid, and comparing the measured characteristic with one obtained with a standard solution containing a known amount of fructosamine and albumin and wherein said standard solution is essentially free of glucose, has a pH of 5.0-6.0 and contains at least 10 mmol/l buffer. 2. The process of claim 1 wherein the albumin is human serum albumin or bovine serum albumin. 3. The process of claim 1 or 2 wherein the standard solution containing albumin is dialyzed, buffered human serum at pH 5.0-6.0. 4. The process of claim 1 or 2 wherein the standard solution has a pH between 5.4 and 5.9. 5. The process of claim 1 or 2 wherein the standard solution has 10 to 70 mmol/l buffer. 6. The process of claim 1 or 2 wherein the buffer is a phosphate buffer. 7. A standard solution for the determination of fructosamine comprising fructosamine, albumin and at least 10 mmol/l buffer, wherein the standard solution has a pH in the range of 5.0 to 6.0 and is essentially free of glucose.

Details for Patent 5,071,767

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2008-12-10
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2008-12-10
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2008-12-10
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978	⤷ Try a Trial	2008-12-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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