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Summary for Patent: 5,028,439
|Title:||Inhibition of parathyroid hormone secretion|
|Abstract:||Parathyroid Hormone, when excessively synthesized, induces pathologic bone resorption and demineralization and results in hypocalcemia which produces toxic effects in soft tissues. Non-toxic water-soluble pharmaceutically acceptable compound derivative of peroxydiphosphoric acid, administered orally or systemically, inhibits parathyroid hormone induced bone resorption in vitro and in vivo in warm blooded animals.|
|Inventor(s):||Gaffar; Abdul (Somerset, NJ)|
|Assignee:||Colgate Palmolive Company (Piscataway, NJ)|
|Patent Claims:||1. A method for inhibiting parathyroid hormone induced bone resorption which comprises administering to a warm blooded mammal host having oversecretion of parathyroid hormone a daily
dosage of about 0.1-6 grams per kilogram body weight when said administration is oral, or about 0.1-2 grams per kilogram body weight when said administration is systemic, of a non-toxic water soluble pharmaceutically acceptable potassium salt of
2. The method claimed in claim 1 wherein said peroxydiphosphate compound is present in amount of about 0.1-7% in a pharmaceutical carrier.
3. The method claimed in claim 2 wherein said peroxydiphosphate compound is present in tabletted granules having a coating thereon which is not broken down during passage through the stomach of said warm blooded animal and which coating is dissolved by intestinal fluids having a pH of 5-10.
4. The method claimed in claim 2 wherein said peroxydiphosphate compound is administered to said warm blooded animal in a solution of non-pyrogenic distilled water and sodium chloride buffered with phosphate.
|Applicant||Tradename||Biologic Ingredient||Dosage Form||BLA||Number||Approval Date||Patent No.||Assignee||Estimated Patent Expiration||Status||Orphan||Source|
|Nps Pharms Inc||NATPARA||parathyroid hormone||INJECTABLE;INJECTION||125511||001||2015-01-23||Start Trial||Colgate Palmolive Company (Piscataway, NJ)||2008-07-02||RX||Orphan||search|
|Nps Pharms Inc||NATPARA||parathyroid hormone||INJECTABLE;INJECTION||125511||002||2015-01-23||Start Trial||Colgate Palmolive Company (Piscataway, NJ)||2008-07-02||RX||Orphan||search|
|Nps Pharms Inc||NATPARA||parathyroid hormone||INJECTABLE;INJECTION||125511||003||2015-01-23||Start Trial||Colgate Palmolive Company (Piscataway, NJ)||2008-07-02||RX||Orphan||search|
|Nps Pharms Inc||NATPARA||parathyroid hormone||INJECTABLE;INJECTION||125511||004||2015-01-23||Start Trial||Colgate Palmolive Company (Piscataway, NJ)||2008-07-02||RX||Orphan||search|
|>Applicant||>Tradename||>Biologic Ingredient||>Dosage Form||>BLA||>Number||>Approval Date||>Patent No.||>Assignee||>Estimated Patent Expiration||>Status||>Orphan||>Source|
|Country||Patent Number||Publication Date|
|Zimbabwe||9585||Nov 13, 1985|
|Zambia||4885||Jan 29, 1987|
|South Africa||8504013||Dec 30, 1986|
|World Intellectual Property Organization (WIPO)||8600225||Jan 16, 1986|
|World Intellectual Property Organization (WIPO)||8606386||Nov 06, 1986|
|United States of America||4575542||Mar 11, 1986|
|>Country||>Patent Number||>Publication Date|
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