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Last Updated: January 26, 2022

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Claims for Patent: 5,023,270

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Summary for Patent: 5,023,270
Title: Antidepressant method of use
Abstract:This invention concerns a pharmaceutical composition useful for treating depression in humans, comprising an effective amount of 5-methoxypsoralen, and optionally, a suitable carrier or diluent, e.g., carboxymethylcellulose, and optionally, a dispersing agent, e.g., polysorbate 80. Also disclosed is a method for treating depression, e.g., endogenous or clinical depression, comprising administering to humans in need of such treatment an effective amount of 5-methoxypsoralen, optionally, a pharmaceutically suitable carrier or diluent, and optionally, a dispersing agent.
Inventor(s): Goupil; Jean-Jacques (94230 Cachan, FR)
Assignee:
Application Number:07/337,814
Patent Claims:1. A method of treating depression in a human in need of such treatment comprising administering at bedtime to a human in need of such treatment, a composition comprising an effective amount of 5-methoxypsoralen.

2. The method of claim 1, said composition further comprising a pharmaceutically suitable carrier or diluent.

3. The method of claim 2, said composition further comprising a dispersing agent.

4. A method according to claim 1, which comprises administering said 5-methoxypsoralen to a human having depression selected from the group consisting of endogenous depression, acute depression, chronic depression, schizophrenia, and dementia, and combinations of two or more of the foregoing illnesses.

5. A method according to claim 1, which comprises administering an effective amount of 5-methoxypsoralen comprising from about 0.02 to about 1 mg/kg body weight per day.

6. A method according to claim 5, wherein the effective amount comprises from about 0.04 to about 0.8 mg/kg body weight per day.

7. A method according to calim 2, which comprises administering a pharmaceutically suitable carrier or diluent selected from the group consisting of carboxymethylcellulose, starch, sterile water, and saline solution, and combinations of two or more of the foregoing.

8. A method according to claim 3, which comprises administering a dispersing agent comprising polysorbate 80.

9. A method according to claim 1, which comprises administering said composition orally.

10. A method according to claim 1, wherein said administration is rectal administration.

11. A method according to claim 1, which comprises administering said composition daily for a period of from about 1 to about 5 weeks.

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Express Scripts
McKinsey
AstraZeneca
Johnson and Johnson
Moodys

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