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Last Updated: March 29, 2024

Claims for Patent: 4,978,391


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Summary for Patent: 4,978,391
Title: Intraoral medicament delivery and procedure
Abstract:A method for cushioning dental appliance in the mouth using a visible light cured polymeric material which can also be used in a method for intraoral medicament delivery in the mouth is provided. When used with an orthodontic bracket, for example, the light cured polymeric material is dispensed on the orthodontic bracket after the bracket is in place and the material is light cured on the bracket. When used in a method of intraoral delivery of a medicament, a medicament is added to the polymeric material and the polymeric material is applied in the same manner as described for cushioning an orthodontic bracket.
Inventor(s): Jones; Leslie A. (York, PA)
Assignee: Dentsply Management Corp. (York, PA)
Application Number:07/331,074
Patent Claims:1. A method for providing intraoral time released delivery of a medicament in the oral cavity comprising the steps of sequentially:

(a) affixing a base to a tooth by applying a dental adhesive to a tooth and/or said base and then touching said base to said tooth,

(b) applying a nontoxic prepolymer of a polyether, polyester, polyurethane, or mixtures thereof containing a medicament to said base said prepolymer comprising a compound of the general formula ##STR1## wherein R.sub.1 may be the same or different

R.sub.3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons, F, Cn and R.sub.3 may be the same or different in each position;

R.sub.4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and

(c) polymerizing to affix the resulting polymeric material to said base and to produce a polymer which is elastomeric, soft and pliable.

2. The method of claim 1 which further comprises the step of selecting said prepolymer to have properties such that said medicament is extracted from said polymeric material by saliva in the oral cavity.

3. The method of claim 1 which comprises the step of providing said base in the form of an orthodontic bracket which is used to straighten teeth.

4. The method of claim 1 which comprises the step of choosing said medicament for the purpose of treating dental.

5. The method of claim 4 which comprises the step of selecting said medicament from the group comprising antiseptics, germicides, antimicrobials, antibiotics, topical anaesthetics, antifungal agents, anti-inflammatory agents, antiviral agents, tooth desensitizing agents, wound healing agents and anti-collagenase agents.

6. The method of claim 1 which comprises the step of adding light activated initiators and accelerators to said prepolymer and adapting said prepolymer to be polymerized using light in the visible wavelength range.

7. The method of claim 6 which comprises the step of selecting said initiator to be camphorquinone.

8. The method of claim 1 comprising the step of affixing said base to said tooth after acid etching said tooth.

9. A method for cushioning dental appliance in the oral cavity comprising the steps of sequentially:

(a) affixing a dental appliance in the mouth by applying a dental adhesive to a tooth and/or said dental appliance and then touching said dental appliance to said tooth,

(b) applying a nontoxic prepolymer of a polyether, polyester, polyurethane, or mixture thereof to said dental appliance said polymer comprising ##STR2## wherein R.sub.1 may be the same or different

R.sub.3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons F, CN and R.sub.3 may be the same or different in each position;

R.sub.4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and

(c) polymerizing said prepolymer to produce an elastic polymer which is soft and pliable using light in the visible wavelength range to affix the resulting polymeric material to said base.

10. The method of claim 9 which comprises the step of using a prepolymer which produces a polymer having hydrophilic properties.

11. The method of claim 9 which comprises the step of including a medicament in said prepolymer for slow release into the oral cavity.

12. An apparatus for intraoral time released delivery of a medicament in the oral cavity comprising:

(a) a base comprising an orthodontic bracket adapted to be affixed to a tooth by adhering said base to said tooth using dental adhesive, and

(b) a nontoxic polymeric material comprising polyether, polyester, polyurethane, or mixtures thereof containing a medicament affixed to said base, said polymer being elastic, soft and pliable said polymer comprising a crosslinked prepolymer comprising ##STR3## wherein R.sub.1 may be the same or different

R.sub.3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, subaryl of 6-14 carbons, F, CN and R.sub.3 may be the same or different in each position;

R.sub.4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acyclic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene.

13. The apparatus according to claim 12 in which said polymeric material has properties such that said medicament is extracted from said polymeric material by saliva in the oral cavity.

14. The apparatus according to claim 12 in which said medicament is adapted to treat dental disease and is selected from the group comprising antiseptics, germicides, antimicrobials, antibiotics, antifungal agents, anti-inflammatory agents, antiviral agents, tooth desensitizing agents, wound healing agents and anti-collagenase agents.

15. The apparatus according to claim 12 in which said polymeric material is a light cured polymeric material.

16. A method of cushioning a dental appliance in the oral cavity and producing intraoral time released delivery of a medicament to the oral cavity comprising the steps of sequentially:

(a) affixing a dental appliance comprising orthodontic brackets to a plurality of teeth by applying a dental adhesive to said brackets and/or said teeth and then touching said brackets to said teeth,

(b) applying a prepolymer of a polyether, polyester, polyurethane or a mixture thereof containing a medicament to said dental appliance said prepolymer comprising ##STR4## wherein R.sub.1 may be the same or different

R.sub.3 is H, alkyl of 2-10 carbons, sub alkyl of 2-10 carbons, aryl of 6-14 carbon, sub aryl of 6-14 carbons, F, CN and R.sub.3 may be the same or different in each position;

R.sub.4 is a divalent hydrocarbon radical or divalent sub hydrocarbon radical and may be straight or branched chain or acrylic or a combination thereof from 2-10 carbons; and is a polyurethane, polyether or polyester backbone; polysiloxanedimethacrylate, and polyorganosilylene, and

(c) polyumerizing said prepolymer to form an elastic, soft, pliable polymer and to at least mechanically attach the resulting polymeric material to said dental appliance.

17. The method of claim 16 which further comprises the step of selecting said prepolymer to have properties such that said medicament is extracted from said polymeric material by saliva in the oral cavity.

18. The method of claim 16 which comprises the step of providing said base in the form of an orthodonic bracket which is used to straighten teeth.

19. The method of claim -6 which comprises the step of choosing said medicament for the purpose of treating dental disease.

20. The method of claim 19 which comprises using a medicament which is a source of fluoride ions.

21. The method of claim 1 wherein said prepolymer is selected from the group consisting of -polydimethyl-silylene-co-phenylmethylsilylene, polycarbonate urethane dimethacrylates, ethoxylated bisphenol A dimethacrylate, 2,2-Bis-propane (BISGMA), and 2,2-Bis-propane (BISIPMA).

22. A method for providing intraoral time released delivery of a medicament in the oral cavity comprising the steps of sequentially:

(a) affixing a base to a tooth by applying a dental adhesive to a tooth and/or said base and then touching said base to a tooth

(b) applying a non-toxic prepolymer of a polyether, polyester, polyurethane, or mixtures thereof containing a medicament to said base, and

(c) polymerizing the prepolymer to affix the resulting polymeric material to said base and to produce an elastomeric polymer.

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