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Last Updated: March 28, 2024

Claims for Patent: 4,833,125


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Summary for Patent: 4,833,125
Title: Method of increasing bone mass
Abstract:A method for increasing bone mass in a human afflicted with osteoporosis or a similar disease which comprises administering to the human so afflicated an effective amount of a composition comprising a parathyroid hormone or physiologically active fragment thereof, or equivalents thereof, in combination with either (a) a hydroxylated Vitamin D compound, or a structural or functional analogue thereof, or (b) a dietary calcium supplement. Pharmaceutical compositions containing the necessary components are also disclosed.
Inventor(s): Neer; Robert M. (Cambridge, MA), Potts, Jr.; John T. (Newton, MA), Slovik; David M. (Newton, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Application Number:07/052,383
Patent Claims:1. A kit useful for administering a bone mass increasing composition comprising a carrier being compartmentalized to receive in close confinement therein one or more containers wherein:

(a) a first container or series of containers contain parathyoid hormone or a physiologically active fragment thereof; said hormone or said fragment obtainable from a human, or other animal;

(b) a second container contains an agent selected from the group consisting of: (i) a hydroxylated Vitamin D compound, and (ii) a dietary calcium supplement, and

(c) a third container contains a buffer for reconstituting or diluting components of said kit.

2. The kit of claim 1 wherein said kit contains means for administering said first agent and said second agent.

3. The kit of claim 1 wherein said first container contains a peptide fragment of parathyroid hormone.

4. The kit of claim 3 wherein said peptide fragment consists of the first 34 amino acid residues from the amino terminal of parathyroid hormone.

5. The kit of claim 1 wherein said synergistic agent is a hydroxylated Vitamin, D compound.

6. The kit of claim 5 wherein said compound is 1-hydroxy Vitamin D.

7. The kit of claim 5 wherein said compound is 1, 25-dihydroxy Vitamin D.

8. The kit of claim 1 wherein said synergistic agent is a dietary calcium supplement.

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