Claims for Patent: 4,808,702

Summary for Patent: 4,808,702

Title:	Decapeptides produced from bioadhesive polyphenolic proteins
Abstract:	Methods are described for the preparation and isolation of novel decapeptides of the formula: ##STR1## wherein each X is independently selected from the group comprising hydroxyl and hydrogen, wherein each R is independently selected from the group comprising hydrogen and methyl, from bioadhesive polyphenolic proteins which comprise: ##STR2## wherein n is a whole number from about 60 to about 100, wherein each X is independently selected from the group comprising hydroxyl and hydrogen, and wherein each R is independently sselected from the group comprising hydrogen and methyl. Such decapeptides may be used to construct large polyphenolic molecules comprising from about 1 to about 1000 decapeptide repeating units and wherein the linking group is selected from the group comprising amino acid, oligopeptide and bifunctional spacer.
Inventor(s):	Waite; J. Herbert (Collinsville, CT)
Assignee:
Application Number:	07/055,450
Patent Claims:	1. A composition prepared by a method which comprises the steps of: (a) isolating bioadhesive proteins from mussel phenol glands; (b) enzymatically digesting said bioadhesive protein; and (c) recovering said decapeptides. 2. A composition prepared by a method which comprises the steps of: (a) isolating from marine mussels bioadhesive polyphenolic proteins which comprise: ##STR10## wherein n is a whole number from about 60 to about 100, wherein each X is independently selected from the group comprising hydroxyl and hydrogen, and wherein each R is independently selected from the group comprising hydrogen and methyl; (b) digesting said bioadhesive proteins with clostridial collagenase; (c) digesting the resultant collagenase-resistant fragment with trypsin; and (d) recovering said decapeptides. 3. A method for the preparation of polyphenolic molecules consisting of from about 1 to about 1000 repeating decapeptide units, which method comprises the step of reacting decapeptides of the formula: ##STR11## wherein each X is independently selected from the group comprising hydroxyl and hydrogen, and wherein each R is independently selected from the group comprising hydrogen and methyl, with a linking group which is selected from the group comprising amino acid, oligopeptide, and bifunctional spacer, in a neutral or slightly basic buffer, at a temperature, and for a period of time until the reaction is substantially complete. 4. Polyphenolic molecules which comprise from about 1 to about 1000 repeating units of the formula: ##STR12## wherein each X is independently selected from the group consisting of hydroxyl and hydrogen and wherein each R is independently selected from the group consisting of hydrogen and methyl, and wherein the repeating units are linked.

Details for Patent 4,808,702

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2004-03-07