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Last Updated: March 28, 2024

Claims for Patent: 4,735,945


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Summary for Patent: 4,735,945
Title: Method for inhibiting bone resorption and collagenase release
Abstract:Method of inhibiting bone resorption and collagenase release in mammalian periodontal subjects using a benzo-c-phenanthridine alkaloid compound.
Inventor(s): Sakamoto; Seizaburo (Chestnut Hill, MA), Sakamoto; Masako (Chestnut Hill, MA)
Assignee: Vipont Laboratories, Inc. (Fort Collins, CO)
Application Number:06/839,229
Patent Claims:1. A method of inhibiting bone resorption and collagenase activity in mammals having periodontal disease, comprising adminstering to said mammals in amount from about 0.2 to about 20 umol/L of sanguinarine, sanguinarine pseudoethanolate or mixtures thereof dissolved in dimethylsulfoxide.

2. The method of claim 1 wherein said sanguinarine is administered in amounts from about 1 to about 20 umol/L.

3. The method of claim 1 wherein sanguinarine pseudoethanolate is administered in amounts from about 0.2 to about 20 umol/L.

4. The method of claim 2 wherein sanguinarine is administered in amount of 20 umol/L.

5. The method of claim 4 wherein sanguinarine pseudoethanolate is administered in amounts of 5 umol/L.

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