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Last Updated: September 22, 2021

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Claims for Patent: 4,732,758

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Summary for Patent: 4,732,758
Title: Preparation with collagenolytic activity having high activity and pharmaceutical compositions containing it
Abstract:The invention relates to a pharmaceutical composition containing in association with a pharmaceutical vehicle a collagenase of high specific activity and capable of being inhibited at least partly by myosine. It is useful for the treatment of pathologies manifested by an uncontrolled alteration of the collagen-rich structures in man or animal.
Inventor(s): Hurion; Nicole (Paris, FR), Keil; Borivog (Gif/S/Yvette, FR)
Assignee: Institut Pasteur (Paris, FR)
Application Number:06/647,674
Patent Claims:1. A composition comprising:

a collagenase which specifically recognizes a peptide sequence X-glycyl-L-prolyl in collagen in an amount effective to treat pathologies manifested by an uncontrolled alteration of collagen-rich structures in man or animal, in which X is a natural amino acid residue linked to the N-terminal end of the glycyl residue, said collagenase cutting said sequence specifically at the level of the X-glycyl linkage to degrade collagen into fragments and besides being inhibited at least partly by myosine;

an effective amount of a neutral protease which can degrade further said collagen fragments; and

an effective amount of an endonuclease which can contribute to the destruction of DNA released as pus by infected cells;

the proportions of said protease and said endonuclease with respect to 0.350 .mu.kat of said collagenase not exceeding 200 caseinolytic units for said protease and 500 nucleasic units for said endonuclease.

2. The composition of claim 1, wherein said collagenase is secreted by Vibrio alginolyticus chemovar iophagus in its culture medium.

3. The composition of claim 2, wherein said collagenase is secreted by the strain deposited at the C.N.C.M. under accession number I-029.

4. The composition of claim 1 which contains a dose of collagenase, expressed by the collagenase activity per weight of the composition, at least equal to 0.05 .mu.kat/g of the pharmaceutical composition.

5. The composition of claim 1 which is a liquid solution for topical use and which contains a dose of collagenase expressed by collagenase activity per volume of liquid, at least equal to 0.05 .mu.kat/ml.

6. The composition of claim 4 which contains from 0.1 to 2 .mu.kat/g of collagenase.

7. The composition of claim 6 which contains from 0.5 to 1 .mu.kat/g of collagenase.

8. The composition of claim 5 which contains from 0.1 to 2 .mu.kat/ml of collagenase.

9. The composition of claim 8 which contains from 0.5 to 1 .mu.kat/g of collagenase.

10. The composition of claim 1 which comprises:

at least 0.350 .mu.kat of said collagenase,

20 to 200 caseinolytic units of said neutral protease and

30 to 500 nucleasic units of said endonuclease.

11. The composition of claim 10 which comprises:

at least 0.350 .mu.kat of said collagenase,

20to 50 caseinolytic units of said neutral protease and

30 to 60 nucleasic units of said endonuclease.

12. The composition of claim 1 which also contains a collagen hydrolysate in the proportion of from 1 to 25 parts by weight of a collagen hydrolysate per part by weight of collagenase.

13. The composition of claim 12 which contains of from 2 to 10 parts by weight of collagen hydrolysate per part by weight of collagenase.

14. The composition of claim 10 which also contains a collagen hydrolysate in the proportion of from 1 to 25 parts by weight of a collagen hydrolysate per part by weight of collagenase.

15. The composition of claim 12 which is freeze-dried and stabilized.

16. The composition of claim 1 which is in the form of a solution for use in the treatment of dental caries or other alterations of the dental pulp in man or animal.

17. A method of treating a skin burn which comprises contacting said burn with an effective amount of the composition of claim 1.

Summary for Patent: ⤷  Free Forever Trial

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
France83 00114Jan 05, 1983
France83 00112Jan 05, 1983

Details for Patent 4,732,758

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Free Forever Trial Institut Pasteur (Paris, FR) 2005-03-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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