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Last Updated: April 25, 2024

Claims for Patent: 4,696,816

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Summary for Patent: 4,696,816

Title:	Method for treating intervertebral disc displacement with enzymes
Abstract:	The method for treating intervertebral disc displacement in mammals which comprises injecting into the intervertebral disc space effective amounts of a pharmacologically suitable solution of the enzyme chondroitinase to bring about the selective chemonucleolysis of the nucleus pulposus.
Inventor(s):	Brown; Mark D. (Miami, FL)
Assignee:
Application Number:	06/796,302
Patent Claims:	1. A method for the treatment of intervertebral disc displacement in humans who have been medically examined and screened for contraindications to chemonucleolysis which comprises administering an effective amount of the cartilage-dissolving enzyme chondroitenase directly into the intervertebral disc space. 2. The method of claim 1 wherein the concentration of chondroitenase constituting the effective amount is 100 units per human disc in the form of 50 units per cc of sterile water without preservatives. 3. A method for the treatment of intervertebral disc displacement in humans who have been medically examined and screened for contraindications to chemonucleolysis which comprises administering an effective amount of the cartilage-dissolving enzyme chondroitenase directly into the intervertebral disc space, said chondroitenase being produced from the bacteria Proteus vulgaris. 4. A method for the treatment of intevertebral disc displacement in humans who have been medically examined and screened for contraindications to chemonucleolysis which comprises administering an effective amount of the cartilage-dissolving enzyme chondroitenase directly into the intervertebral disc space, said chondroitenase being produced from the bacteria Arthrobacter auerescens. 5. A pharmaceutical composition comprising a sterile solution containing as an active ingredient chondroitenase in an admixture with sterile water without preservatives, said solution being adapted to be injected into a patient for the treatment of intervertebral disc displacement.

Details for Patent 4,696,816

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006	⤷ Try a Trial	2039-09-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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