You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 4,677,058


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 4,677,058
Title: Detecting malignant cells with monoclonal antibodies specific to type IV collagenase enzyme
Abstract:Basement membrane collagen degrading enzymes are provided which are useful for the detection of malignant cells with metastatic activity. Means for detecting such cells are also provided.
Inventor(s): Tryggvason; Karl (90230 Oulu 23, FI), Liotta; Lance A. (Bethesda, MD)
Assignee:
Application Number:06/496,230
Patent Claims:1. A method of detecting malignant cells with metastatic cell activity comprising:

a. preparing monoclonal antibodies that bind specifically to type IV collagenase enzyme antigen;

b. adding said monoclonal antibodies to a biological sample of the subject to be tested; and

c. measuring the antigen-monoclonal antibody reaction in said biological sample.

2. The method of claim 1, wherein the monoclonal antibodies that bind specifically to type IV collagenase enzyme antigens are labelled.

3. The method of claim 1, wherein the monoclonal antibodies that bind specifically to type IV collagenase enzyme antigens are coupled to solid carriers.

4. A method of detecting malignant cells with metastatic cell activity comprising:

a. preparing monoclonal antibodies that bind specifically to type IV collagenase enzyme antigen;

b. preparing second antibodies to said monoclonal antibodies;

c. labelling said second antibodies;

d. adding the monoclonal antibodies to a biological sample of the subject to be tested;

e. incubating the biological samples containing the monoclonal antibodies;

f. adding the second labelled antibodies to the biological sample containing the monoclonal antibodies; and

g. measuring the antigen-monoclonal antibody-second labelled antibody reaction in said biological sample.

5. A method of detecting malignant cells with metastatic cell activity comprising:

a. preparing monoclonal antibodies that bind specifically to type IV collagenase enzyme antigen;

b. labelling type IV collagenase enzyme antigens;

c. adding said monoclonal antibodies and said labelled type IV collagenase enzyme antigens to biological samples of the subject to te tested;

d. incubating the resultant mixture; and

e. measuring the antigen-monoclonal antibody and the labelled antigen-monoclonal antibody reactions in said biological sample.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.