Claims for Patent: 4,636,195

Summary for Patent: 4,636,195

Title:	Method and apparatus for removing arterial constriction
Abstract:	A catheter is described with distal and proximate balloon segments expansible to produce a chamber around arterial plaque and a conduit for delivering solubilizing liquid into the chamber. The catheter may also contain a central expansible balloon to assist in forcing the liquid into the plaque and to compress the plaque. Several solubilizing liquids are described.
Inventor(s):	Wolinsky; Harvey (New York, NY)
Assignee:
Application Number:	06/720,453
Patent Claims:	1. A cathether adapted for insertion into an artery for relieving arterial constriction caused by a body of plaque comprising a main catheter body having means including two spaced balloon elements adapted to be positioned adjacent respective proximate and distal ends of the plaque body and expansible against the arterial walls for providing a chamber about said plaque body so as to hold said main catheter body in place, means carried by said main catheter body for delivering a solution into said chamber for solubilizing said plaque body, and means including a third balloon element disposed intermediate said two spaced balloon elements and expansible for forcing said solution into said plaque body while compressing said plaque body. 2. A catheter according to either claim 1, each of said two spaced balloon elements having a length ranging from about 2 mm to 5 mm and being expansible to a diameter from about 2 mm to 5 mm. 3. A catheter according to claim 1 or claim 2, said third balloon element having a length ranging from about 10 mm to 5 mm and being expansible to a diameter ranging from about 2 mm to 5 mm. 4. A catheter according to claim 1, said two spaced balloon elements being expansible by fluid pressure and adapted to remain in a stable, expanded condition at about 5 atmospheres of pressure. 5. A method for relieving a constriction in an artery caused by a body of plaque which comprises the steps of: 1. inserting into the artery a catheter comprising a main catheter body having means including two spaced balloon elements adapted to be positioned adjacent respective proximate and distal ends of the plaque body and expansible to the arterial diameter of the constricted artery against the arterial walls for providing a chamber about said plaque body so as to hold said main catheter body in place, and means carried by said main catheter body for delivering a solution under pressure into said chamber and said plaque for solubilizing said plaque body, 2. inflating said two spaced balloon elements, 3. delivering a solubilizing solution into said chamber through said solution delivering means, 4. deflating said balloon elements, and 5. removing the catheter from the artery. 6. A method for relieving an arterial constriction caused by a body of plaque which comprises the steps of: 1. inserting into the artery a catheter comprising a main catheter body having means including two spaced balloon elements adapted to be positioned adjacent respective proximate and distal ends of the plaque body and expansible against the arterial walls for providing a chamber about said plaque body so as to hold said main catheter body in place, means carried by said main catheter body for delivering a solutin under pressure into said chamber and said plaque for solubilizing said plaque body and means including a third expansible balloon element disposed intermediate said two spaced balloon elements, 2. inflating said two spaced balloon elements, 3. delivering a solubilizing solution into said chamber through said colution delivering means, 4. inflating said third balloon element, 5. deflating said balloon elements, 6. removing the catheter from the artery. 7. A method as in claim 6 wherein Steps 3 and 4 are performed simultaneously. 8. A method for relieving a constriction in an artery caused by a body of plaque which comprises the steps of: 1. inserting into the artery a catheter comprising a main catheter body having means including two spaced balloon elements adapted to be positioned adjacent respective proximate and distal ends of the plaque body and expansible to the arterial diameter of the constricted artery against the arterial walls for providing a chamber about said plaque body so as to hold said main catheter body in place, means carried by said main catheter body for delivering a solution under pressure into said chamber and said plaque for solubilizing said plaque body, 2. inflating said two spaced balloon elements, 3. delivering a solubilizing solution into said chamber through said solution delivering means, 4. deflating said balloon elements, and 5. removing the catheter from the artery; said solubilizing solution comprising an isotonic aqueous buffered mixture at a pH of from 7.2 to 7.6 of at least one phospholipid and at least one bile acid, having a solids content of from about 10% to 30% by volume and a water content of from 90% to 10% by volume the ratio of bile acid to phospholipid being from 50:50 to 85:15 by weight. 9. A method as in claim 8 wherein the phospholipid is a lecithin. 10. A method as in claim 9 wherein the bile acid is selected from the group consisting of cholic, deoxycholic, taurocholic and glycocholic acids. 11. A method as in claims 8, 9 or 10 wherein the solubilizing solution additionally contains from about 20 to 400 .mu.g/cc of solution of collagenase.

Details for Patent 4,636,195

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2039-03-29