Claims for Patent: 4,596,675

Summary for Patent: 4,596,675

Title:	Novel thiopeptolide substrates for vertebrate collagenase
Abstract:	The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences: wherein R=H or N-protecting group, X=Leu, Ile, Phe, Val, Gln, Ala, Y=Leu, Ile, Phe, Val, Ala, Z=Leu, Ile, Phe, Val, Gln, Ala, and R.sub.1 =terminal amide, carboxyl or ester group.
Inventor(s):	Weingarten; Harold I. (University City, MO), Feder; Joseph (University City, MO)
Assignee:	Monsanto Company (St. Louis, MO)
Application Number:	06/780,116
Patent Claims:	1. A thiopeptolide having activity as a substrate for vertebrate collagenase selected from the group consisting of: wherein R=H or N-protecting group, X=Leu, Ile, Phe, Val, Gln, Ala, Y=Leu, Ile, Phe, Val, Ala, Z=Leu, Ile, Phe, Val, Gln, Ala, R.sub.1 =terminal amide, carboxyl or ester group, and the pharmaceutically acceptable salts thereof. 2. The thiopeptolide of claim 1 in which X=Leu or Ala, Y=Leu, and Z=Leu, Ala or Phe. 3. The thiopeptolide of claim 2 having the structure 4. The thiopeptolide of claim 2 having the structure 5. The thiopeptolide of claim 2 having the structure 6. The thiopeptolide of claim 2 having the structure

Details for Patent 4,596,675

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2004-01-16