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Last Updated: September 22, 2021

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Claims for Patent: 4,596,675

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Summary for Patent: 4,596,675
Title: Novel thiopeptolide substrates for vertebrate collagenase
Abstract:The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences: wherein R=H or N-protecting group, X=Leu, Ile, Phe, Val, Gln, Ala, Y=Leu, Ile, Phe, Val, Ala, Z=Leu, Ile, Phe, Val, Gln, Ala, and R.sub.1 =terminal amide, carboxyl or ester group.
Inventor(s): Weingarten; Harold I. (University City, MO), Feder; Joseph (University City, MO)
Assignee: Monsanto Company (St. Louis, MO)
Application Number:06/780,116
Patent Claims:1. A thiopeptolide having activity as a substrate for vertebrate collagenase selected from the group consisting of:

wherein

R=H or N-protecting group,

X=Leu, Ile, Phe, Val, Gln, Ala,

Y=Leu, Ile, Phe, Val, Ala,

Z=Leu, Ile, Phe, Val, Gln, Ala,

R.sub.1 =terminal amide, carboxyl or ester group,

and the pharmaceutically acceptable salts thereof.

2. The thiopeptolide of claim 1 in which

X=Leu or Ala,

Y=Leu, and

Z=Leu, Ala or Phe.

3. The thiopeptolide of claim 2 having the structure

4. The thiopeptolide of claim 2 having the structure

5. The thiopeptolide of claim 2 having the structure

6. The thiopeptolide of claim 2 having the structure

Details for Patent 4,596,675

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Free Forever Trial Monsanto Company (St. Louis, MO) 2004-01-16 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 4,596,675

Country Patent Number Estimated Expiration
Australia 3770585 ⤷  Free Forever Trial
Australia 569934 ⤷  Free Forever Trial
Canada 1283500 ⤷  Free Forever Trial
Germany 3576825 ⤷  Free Forever Trial
European Patent Office 0149593 ⤷  Free Forever Trial
Japan S60208999 ⤷  Free Forever Trial
United States of America 4569907 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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